Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+).

Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+). Research Abstract Details 

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Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+). Abstract Text:

Shidi Zhao,Na Chen,Zhilai Yang,Li Huang,Yan Zhu,Sudong Guan,Qianfen Chen,Jin-Hui Wang,Shidi Zhao,Na Chen,Zhilai Yang,Li Huang,Yan Zhu,Sudong Guan,Qianfen Chen,Jin-Hui Wang,Shidi Zhao,Na Chen,Zhilai Yang,Li Huang,Yan Zhu,Sudong Guan,Qianfen Chen,Jin-Hui Wang,

Ischemia-induced excitotoxicity at cerebellar Purkinje cells is presumably due to a persistent glutamate action. To the fact that they are more vulnerable to ischemia than other glutamate-innervated neurons, we studied whether additional mechanisms are present and whether cytoplasm Ca(2+) plays a key role in their ischemic excitotoxicity. Ischemic changes in the excitability of Purkinje cells were measured by whole-cell recording in cerebellar slices of rats with less glutamate action. The role of cytoplasm Ca(2+) was examined by two-photon cellular imaging and BAPTA infusion in Purkinje cells. Lowering perfusion rate to cerebellar slices deteriorated spike timing and raised spike capacity of Purkinje cells. These changes were associated with the reduction of spike refractory periods and threshold potentials, as well as the loss of their control to spike encoding. Ischemia-induced functional deterioration at Purkinje neurons was accompanied by cytoplasm Ca(2+) rise and prevented by BAPTA infusion. Therefore, the ischemia destabilizes the spike encoding of Purkinje cells via raising cytoplasm Ca(2+) without a need for glutamate, which subsequently causes their excitotoxic death.

Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+). Publishing Authors By Initials

S Zhao,N Chen,Z Yang,L Huang,Y Zhu,S Guan,Q Chen,JH Wang,S Zhao,N Chen,Z Yang,L Huang,Y Zhu,S Guan,Q Chen,JH Wang,S Zhao,N Chen,Z Yang,L Huang,Y Zhu,S Guan,Q Chen,JH Wang,

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Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 366

Page Numbers: 401-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 10

MONTH: 12

YEAR: 2007

Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+). Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca(2+).

AFFILIATION: Department of Physiology, Bengbu Medical College, Bengbu Anhui 233000, China.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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