Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Research Abstract Details 

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Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Abstract Text:

Wenhua Chu,Justin Rothfuss, d'Avignon,Chenbo Zeng,Dong Zhou,Richard S Hotchkiss,Robert H Mach,

A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated. These compounds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspase-7, and have a low potency for inhibiting caspase-1, caspase-6, and caspase-8. The inhibition mechanism was investigated through NMR studies of the reaction between 11d and benzylmercaptan as a model for Cys-285 in the active site of caspase-3.

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Publishing Authors By Initials

W Chu,J Rothfuss,A d'Avignon,C Zeng,D Zhou,RS Hotchkiss,RH Mach,

For similar organic chemicals: amides: sulfonamides research abstracts see: organic chemicals: amides: sulfonamides research

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MEDLINE DATE:

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 3751-5

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 23

MONTH: 06

YEAR: 2007

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716531

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Keywords Mesh Terms:

KEYWORDS: Sulfonamides

MESH TERMS: chemistry

Chemical & Substance for Abstract: Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Information

Substance Name: Caspase 7

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

AFFILIATION: Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL13851

ACRONYM: HL

MEDLINETA: J Med Chem

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