Is renin a risk factor?

Is renin a risk factor? Research Abstract Details 

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Is renin a risk factor? Abstract Text:

W M Kirkendall,M L Overturf,R E Druilhet,

1. These results show that elevated blood pressure and a hyperlipidemic diet exacerbate atherogenesis in the two kidney, one-clip hypertensive rabbit. Elevated PRA activity was not essential for the hypertension and did not exacerbate atherogenesis. 2. In addition, the experimentally induced, low renin state following DOC-saline did not result in a protective effect on cardiovascular lesions in rabbits fed an atherogenic diet when compared to normal renin controls. 3. Thus, in these experiments neither an increase in plasma renin accelerated atherogenesis, nor did a decrease in PRA slow the rate of production of atherosclerosis in the rabbit. 4. These observations lend no support to the thesis that renin is an independent risk factor when it is generated within the body in response to these stimuli. Indeed, it suggests that in this setting other factors, not PRA, are responsible for both hypertension in the two-kidney, one-clip rabbit and the arterial damage which occurs in this hypercholesterolemic model.

Is renin a risk factor? Publishing Authors By Initials

WM Kirkendall,ML Overturf,RE Druilhet,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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Is renin a risk factor? Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Transactions of the American Clinical and Climatol

VOLUME: 92

Page Numbers: 216-26

Journal Abbreviation: Trans. Am. Clin. Climatol. Ass

ISSN: 0065-7778

DAY: 29

MONTH: 01

YEAR: 1981

Is renin a risk factor? Information

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LANGUAGE: eng

NlmUniqueID: 7507559

Is renin a risk factor? Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: etiology

Chemical & Substance for Abstract: Is renin a risk factor? Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Is renin a risk factor?

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: HL-20189

ACRONYM: HL

MEDLINETA: Trans Am Clin Climatol Assoc

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