Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience.

Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Research Abstract Details 

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Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Abstract Text:

Philippe Goupille,Denis Mulleman,Xavier Chevalier,Philippe Goupille,Denis Mulleman,Xavier Chevalier,

IL-1 plays a key role in disc degeneration and could be a valid target for inhibiting this process. IL-1 receptor antagonist (IL-1ra) might be a good candidate to inhibit IL-1 activity. However, many questions need to be addressed before contemplating therapy in humans. IL-1 blockade is also a great challenge in osteoarthritis and results from animal models suggest that IL-1ra may have beneficial effects. The clinical benefit of a local injection of IL-1ra in knee osteoarthritis may be limited by the antagonist's short half-life. Further studies with longer-lasting antagonists are needed to explore this new therapeutic approach.

Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Publishing Authors By Initials

P Goupille,D Mulleman,X Chevalier,P Goupille,D Mulleman,X Chevalier,

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Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Journal Published:

PUBLICATION TYPE: Editorial

Journal: Arthritis research & therapy

VOLUME: 9

Page Numbers: 110

Journal Abbreviation: Arthritis Res. Ther.

ISSN: 1478-6362

DAY: 18

MONTH: 02

YEAR: 2007

Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Information

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LANGUAGE: eng

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Country: England

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MEDLINETA: Arthritis Res Ther

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