Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance.

Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Research Abstract Details 

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Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Abstract Text:

Yutaka Kohgo,Katsuya Ikuta,Takaaki Ohtake,Yoshihiro Torimoto,Junji Kato,

There are several cofactors which affect body iron metabolism and accelerate iron overload. Alcohol and hepatic viral infections are the most typical examples for clarifying the role of cofactors in iron overload. In these conditions, iron is deposited in hepatocytes and Kupffer cells and reactive oxygen species (ROS) produced through Fenton reaction have key role to facilitate cellular uptake of transferrin-bound iron. Furthermore, hepcidin, antimicrobial peptide produced mainly in the liver is also responsible for intestinal iron absorption and reticuloendothelial iron release. In patients with ceruloplasmin deficiency, anemia and secondary iron overload in liver and neurodegeneration are reported. Furthermore, there is accumulating evidence that fatty acid accumulation without alcohol and obesity itself modifies iron overload states. Ineffective erythropoiesis is also an important factor to accelerate iron overload, which is associated with diseases such as thalassemia and myelodysplastic syndrome. When this condition persists, the dietary iron absorption is increased due to the increment of bone marrow erythropoiesis and tissue iron overload will thereafter occurs. In porphyria cutanea tarda, iron is secondarily accumulated in the liver.

Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Publishing Authors By Initials

Y Kohgo,K Ikuta,T Ohtake,Y Torimoto,J Kato,

For similar nutritional and metabolic diseases: nutrition disorders: overnutrition: obesity research abstracts see: nutritional and metabolic diseases: nutrition disorders: overnutrition: obesity research

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Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Journal Published:

PUBLICATION TYPE: Review

Journal: World journal of gastroenterology : WJG

VOLUME: 13

Page Numbers: 4699-706

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 21

MONTH: Sep

YEAR: 2007

Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Information

Number of References: 84

LANGUAGE: eng

NlmUniqueID: 100883448

Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Keywords Mesh Terms:

KEYWORDS: Obesity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance.

AFFILIATION: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Midorigaoka-higashi 2-1, Asahikawa 078-8510, Japan. yk1950@asahikawa-med.ac.jp

Country: China

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MEDLINETA: World J Gastroenterol

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