Iron in chronic brain disorders: imaging and neurotherapeutic implications.

Iron in chronic brain disorders: imaging and neurotherapeutic implications. Research Abstract Details 

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Iron in chronic brain disorders: imaging and neurotherapeutic implications. Abstract Text:

James Stankiewicz,S Scott Panter,Mohit Neema,Ashish Arora,Courtney E Batt,Rohit Bakshi,

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.

Iron in chronic brain disorders: imaging and neurotherapeutic implications. Publishing Authors By Initials

J Stankiewicz,SS Panter,M Neema,A Arora,CE Batt,R Bakshi,

For similar nervous system diseases: neurodegenerative diseases research abstracts see: nervous system diseases: neurodegenerative diseases research

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Iron in chronic brain disorders: imaging and neurotherapeutic implications. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurotherapeutics : the journal of the American So

VOLUME: 4

Page Numbers: 371-86

Journal Abbreviation:

ISSN: 1933-7213

DAY: 3

MONTH: Jul

YEAR: 2007

Iron in chronic brain disorders: imaging and neurotherapeutic implications. Information

Number of References: 182

LANGUAGE: eng

NlmUniqueID: 101290381

Iron in chronic brain disorders: imaging and neurotherapeutic implications. Keywords Mesh Terms:

KEYWORDS: Neurodegenerative Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Iron in chronic brain disorders: imaging and neurotherapeutic implications. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Iron in chronic brain disorders: imaging and neurotherapeutic implications.

AFFILIATION: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NINDS

GRANT: K23 NS042379-04

ACRONYM: NS

MEDLINETA: Neurotherapeutics

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