Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.

Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Research Abstract Details 

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Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Abstract Text:

A chemo- and regioselective cross-coupling reaction of the functionalized aryl triflate 5 with octylmagnesium bromide catalyzed by cheap, nontoxic, and environmentally benign Fe(acac)(3) sets the basis for a practical and scaleable synthesis of the octylbenzene derivative 6, which serves as a key building block for the preparation of FTY720 (1). This 2-amino-1,3-propanediol derivative shows highly promising immunosuppressive properties and is currently in human clinical phase III trials.

Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Publishing Authors By Initials

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Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of organic chemistry

VOLUME: 69

Page Numbers: 3950-2

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 28

MONTH: May

YEAR: 2004

Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Keywords Mesh Terms:

KEYWORDS: Sphingosine

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.

AFFILIATION: Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany fuerstner@mpi-muelheim.mpg.de

Country: United States

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MEDLINETA: J Org Chem

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