Iron and oxygen: a biologically damaging mixture.

Iron and oxygen: a biologically damaging mixture. Research Abstract Details 

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Iron and oxygen: a biologically damaging mixture. Abstract Text:

J M Gutteridge,

Iron is a remarkably useful metal in Nature, but iron ions not safely sequestered in storage or transport proteins are hazardous because they can stimulate damaging free radical reactions. Biological examples of these are Fenton Chemistry leading to the formation of highly reactive species, such as the hydroxyl radical (.OH) and the ferryl ion (FeO2+), and lipid peroxidation. The need to conserve body iron stores has closely evolved with an essential requirement for antioxidant protection and, several 'acute-phase' proteins involved in iron metabolism such as caeruloplasmin, haptoglobins and haemopexin in collaboration with the iron binding proteins transferrin and lactoferrin contribute to our defense against oxidative damage.

Iron and oxygen: a biologically damaging mixture. Publishing Authors By Initials

JM Gutteridge,

For similar inorganic chemicals: elements: chalcogens: oxygen research abstracts see: inorganic chemicals: elements: chalcogens: oxygen research

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Iron and oxygen: a biologically damaging mixture. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta paediatrica Scandinavica. Supplement

VOLUME: 361

Page Numbers: 78-85

Journal Abbreviation:

ISSN: 0300-8843

DAY: 20

MONTH: 02

YEAR: 1989

Iron and oxygen: a biologically damaging mixture. Information

Number of References: 55

LANGUAGE: eng

NlmUniqueID: 173166

Iron and oxygen: a biologically damaging mixture. Keywords Mesh Terms:

KEYWORDS: Oxygen

MESH TERMS: metabolism

Chemical & Substance for Abstract: Iron and oxygen: a biologically damaging mixture. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Iron and oxygen: a biologically damaging mixture.

AFFILIATION: Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Country: SWEDEN

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MEDLINETA: Acta Paediatr Scand Suppl

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