IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly.

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Research Abstract Details 

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IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Abstract Text:

Lorena B ,Ho-Man Kan,Ningning Wang,Horst Wallrabe,Lance A Davidson,Ying Cai,Dorothy A Schafer,George S Bloom,

IQGAP1 has been implicated as a regulator of cell motility because its overexpression or underexpression stimulates or inhibits cell migration, respectively, but the underlying mechanisms are not well understood. Here, we present evidence that IQGAP1 stimulates branched actin filament assembly, which provides the force for lamellipodial protrusion, and that this function of IQGAP1 is regulated by binding of type 2 fibroblast growth factor (FGF2) to a cognate receptor, FGFR1. Stimulation of serum-starved MDBK cells with FGF2 promoted IQGAP1-dependent lamellipodial protrusion and cell migration, and intracellular associations of IQGAP1 with FGFR1--and two other factors--the Arp2/3 complex and its activator N-WASP, that coordinately promote nucleation of branched actin filament networks. FGF2 also induced recruitment of IQGAP1, FGFR1, N-WASP and Arp2/3 complex to lamellipodia. N-WASP was also required for FGF2-stimulated migration of MDBK cells. In vitro, IQGAP1 bound directly to the cytoplasmic tail of FGFR1 and to N-WASP, and stimulated branched actin filament nucleation in the presence of N-WASP and the Arp2/3 complex. Based on these observations, we conclude that IQGAP1 links FGF2 signaling to Arp2/3 complex-dependent actin assembly by serving as a binding partner for FGFR1 and as an activator of N-WASP.

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Publishing Authors By Initials

LB ,HM Kan,N Wang,H Wallrabe,LA Davidson,Y Cai,DA Schafer,GS Bloom,

For similar peptides: intracellular signaling peptides and proteins: gtp-binding protein regulators: gtpase-activating proteins: ras gtpase-activating proteins research abstracts see: peptides: intracellular signaling peptides and proteins: gtp-binding protein regulators: gtpase-activating proteins: ras gtpase-activating proteins research

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IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 658-69

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 30

MONTH: 01

YEAR: 2007

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 52457

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Keywords Mesh Terms:

KEYWORDS: ras GTPase-Activating Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. Information

Substance Name: Fibroblast Growth Factor 2

Registry Number: 103107-01-3

Grant and Affiliation Information for IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly.

AFFILIATION: Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.

Country: England

AGENCY: United States NIDDK

GRANT: P30 DK067629

ACRONYM: DK

MEDLINETA: J Cell Sci

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