Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Research Abstract Details 

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Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Abstract Text:

Emma M J King,Najma Rachidi,Nick Morrice,Kevin G Hardwick,Michael J R Stark,Emma M J King,Najma Rachidi,Nick Morrice,Kevin G Hardwick,Michael J R Stark,

The spindle checkpoint delays anaphase onset until all chromosomes are correctly attached to microtubules. Ipl1 protein kinase (Aurora B) is required to correct inappropriate kinetochore-microtubule attachments and for the response to lack of tension between sister kinetochores. Here we identify residues in the checkpoint protein Mad3p that are phosphorylated by Ipl1p. When phosphorylation of Mad3p at two sites is prevented, the cell's response to reduced kinetochore tension is dramatically curtailed. Our data provide strong evidence for a distinct checkpoint pathway responding to lack of sister kinetochore tension, in which Ipl1p-dependent phosphorylation of Mad3p is a key step.

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Publishing Authors By Initials

EM King,N Rachidi,N Morrice,KG Hardwick,MJ Stark,EM King,N Rachidi,N Morrice,KG Hardwick,MJ Stark,

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Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes & development

VOLUME: 21

Page Numbers: 1163-8

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 15

MONTH: May

YEAR: 2007

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Information

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LANGUAGE: eng

NlmUniqueID: 8711660

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Grant and Affiliation Information for Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

AFFILIATION: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: 067210

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MEDLINETA: Genes Dev

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