Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans.

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Abstract Text:

Akira Fujimori,Takeshi Yaoi,Hiroshi Ogi,Bing Wang,Katsutoshi Suetomi,Emiko Sekine,Dong Yu,Takamitsu Kato,Sentaro Takahashi,Ryuichi Okayasu,Kyoko Itoh,Shinji Fushiki,Akira Fujimori,Takeshi Yaoi,Hiroshi Ogi,Bing Wang,Katsutoshi Suetomi,Emiko Sekine,Dong Yu,Takamitsu Kato,Sentaro Takahashi,Ryuichi Okayasu,Kyoko Itoh,Shinji Fushiki,

Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated in irradiated human diploid fibroblasts. ASPM was recently reported as the causative gene for MCPH-5, the most common type of congenital microcephaly in humans. Here, we show that the expression of the Aspm gene was significantly reduced by IR in various human and murine cells. Additionally, Aspm was found downregulated in the irradiated fetal mouse brain, particularly in the ventricular zones. A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation.

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Publishing Authors By Initials

A Fujimori,T Yaoi,H Ogi,B Wang,K Suetomi,E Sekine,D Yu,T Kato,S Takahashi,R Okayasu,K Itoh,S Fushiki,A Fujimori,T Yaoi,H Ogi,B Wang,K Suetomi,E Sekine,D Yu,T Kato,S Takahashi,R Okayasu,K Itoh,S Fushiki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 369

Page Numbers: 953-7

Journal Abbreviation:

ISSN: 1090-2104

DAY: 10

MONTH: 03

YEAR: 2008

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans.

AFFILIATION:

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans Related Publications

• A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6).
• Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release.
• Intracisternal administration of transforming growth factor- evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells.
• Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans.
• Lysophospholipid receptors are differentially expressed in rat terminal schwann cells, as revealed by a single cell rt-PCR and in situ hybridization.
• Mercaptoacetate inhibition of fatty acid {beta}-oxidation attenuates the oral acceptance of fat in BALB/c mice.
• Reinforcing effect for corn oil stimulus was concentration dependent in an operant task in mice.
• Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus.
• Why is fat so tasty? Chemical reception of fatty acid on the tongue.