Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease.

Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Research Abstract Details 

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Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Abstract Text:

E Hashimoto,K Mizuta,Y Sakanoue,H Yamamura,

Protein kinase C, reversibly bound to rat liver plasma membrane through Ca2+, was activated by endogenous trypsin-like protease in an ionic strength-dependent manner. In an attempt to understand the reaction mechanism, the EGTA-extracted protein kinase C and the trypsin-like protease (Tanaka, K. et al. (1986) J. Biol. Chem. 261, 2610-2615) were separately purified from plasma membrane. In the reaction system using these purified enzymes, increasing the ionic strength with NaCl (140-210 mM) effectively enhanced the proteolytic activation of the protein kinase C in the presence of Ca2+ and phospholipid. These results suggest that ionic strength is an important factor for the proteolytic activation of membrane-bound rat liver protein kinase C.

Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Publishing Authors By Initials

E Hashimoto,K Mizuta,Y Sakanoue,H Yamamura,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research

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Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 104

Page Numbers: 934-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1988

Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Keywords Mesh Terms:

KEYWORDS: Trypsin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease. Information

Substance Name: Trypsin

Registry Number: EC 3.4.21.4

Grant and Affiliation Information for Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease.

AFFILIATION: Department of Biochemistry, Fukui Medical School.

Country: JAPAN

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MEDLINETA: J Biochem

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