Ion selectivity in potassium channels.

Ion selectivity in potassium channels. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ion selectivity in potassium channels. Abstract Text:

Sergei Yu Noskov, Roux,

Potassium channels are tetrameric membrane-spanning proteins that provide a selective pore for the conduction of K(+) across the cell membranes. One of the main physiological functions of potassium channels is efficient and very selective transport of K(+) ions through the membrane to the cell. Classical views of ion selectivity are summarized within a historical perspective, and contrasted with the molecular dynamics (MD) simulations free energy perturbation (FEP) performed on the basis of the crystallographic structure of the KcsA phospholipid membrane. The results show that the KcsA channel does not select for K(+) ions by providing a binding site of an appropriate (fixed) cavity size. Rather, selectivity for K(+) arises directly from the intrinsic local physical properties of the ligands coordinating the cation in the binding site, and is a robust feature of a pore symmetrically lined by backbone carbonyl groups. Further analysis reveals that it is the interplay between the attractive ion-ligand (favoring smaller cation) and repulsive ligand-ligand interactions (favoring larger cations) that is the basic element governing Na(+)/K(+) selectivity in flexible protein binding sites. Because the number and the type of ligands coordinating an ion directly modulate such local interactions, this provides a potent molecular mechanism to achieve and maintain a high selectivity in protein binding sites despite a significant conformational flexibility.

Ion selectivity in potassium channels. Publishing Authors By Initials

SY Noskov,B Roux,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

PUBMED ID PMID:

MEDLINE DATE:

Ion selectivity in potassium channels. Journal Published:

PUBLICATION TYPE: Review

Journal: Biophysical chemistry

VOLUME: 124

Page Numbers: 279-91

Journal Abbreviation: Biophys. Chem.

ISSN: 0301-4622

DAY: 18

MONTH: 06

YEAR: 2006

Ion selectivity in potassium channels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 403171

Ion selectivity in potassium channels. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: chemistry

Chemical & Substance for Abstract: Ion selectivity in potassium channels. Information

Substance Name: Sodium

Registry Number: 7440-23-5

Grant and Affiliation Information for Ion selectivity in potassium channels.

AFFILIATION: Institute for Molecular Pediatric Sciences and Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Sciences, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM062342

ACRONYM: GM

MEDLINETA: Biophys Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ion selectivity in potassium channels Related Publications

• A new optimization approach for the calibration of an ultrasound probe using a 3D optical localizer.
• A proton-controlled check valve for sodium ion transport.
• A review of image watermarking applications in healthcare.
• Analysing Gene Regulatory Networks by both Constraint Programming and Model-Checking.
• Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck.
• Characterization of conformational equilibria through Hamiltonian and temperature replica-exchange simulations: assessing entropic and environmental effects.
• Correction to "solvation and polarization of the N-methyl amine molecule in aqueous solution: a combined study of quantum mechanics and integral equation theory in three dimensions" by qishi du and dongqing wei.
• Detection of lesions in retina photographs based on the wavelet transform.
• Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment.
• Ellipsoid-Constrained Robust Fitting of Quadrics with Application to the 3D Morphological Characterization of Articular Surfaces.
• Evaluation of 3D Anatomical Surfaces Indexing for Surgery Planning.
• Fluorescent TiO2 powders prepared using a new perylene diimide dye: applications in latent fingermark detection.
• Functional association of Sun1 with nuclear pore complexes.
• Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels.
• In vivo 3D reconstruction of human vertebrae with the three-dimensional X-ray absorptiometry (3D-XA) method.
• Insertion of GPI-anchored alkaline phosphatase into supported membranes: a combined AFM and fluorescence microscopy study.
• Ion selectivity in potassium channels.
• Mixed Reversible and RONI Watermarking for Medical Image Reliability Protection.
• Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol.
• Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels.
• Molecular dynamics study of hydration in ethanol-water mixtures using a polarizable force field.
• Multimedia medical case retrieval using decision trees.
• On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
• Prevention of volatile fatty acids production and limitation of odours from winery wastewaters by denitrification.
• The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain.
• [Hypersensitivity of the skin to picric acid; simulation of accident.]
• [In Process Citation]
• [Not Available.]
• [Not Available.]
• d-Gallocatechin from the bark of Casuarina equisetifolia Linn.