Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma.

Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. Research Abstract Details 

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Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. Abstract Text:

Yi Xie,Hiuman Chan,Jianqing Fan,Yongxiong Chen,Joseph Young,Wen Li,Xiaoping Miao,Zhengwei Yuan,Huanmin Wang,Paul K H Tam,Yi Ren,Yi Xie,Hiuman Chan,Jianqing Fan,Yongxiong Chen,Joseph Young,Wen Li,Xiaoping Miao,Zhengwei Yuan,Huanmin Wang,Paul K H Tam,Yi Ren,Yi Xie,Hiuman Chan,Jianqing Fan,Yongxiong Chen,Joseph Young,Wen Li,Xiaoping Miao,Zhengwei Yuan,Huanmin Wang,Paul K H Tam,Yi Ren,

Tumor growth and metastasis require that tumor cells must have either the potential to shift genetically or epigenetically between proliferative and invasive phenotypes or both phenotypes simultaneously. In the present study, we demonstrated that neuroblastoma growth and invasion were distinct processes that were carried out by proliferative and invasive phenotypes of tumor cells, respectively. Two subpopulations from human neuroblastoma cell line were isolated: highly invasive (HI) cells and low-invasive (LI) cells. HI and LI cells had different proliferative rate and metastatic ability in vitro and in vivo. In addition, they had distinct activated signal pathways and sensitivities to chemotherapy drugs. Affymetrix microarray and quantitative reverse transcriptase-polymerase chain reaction revealed that visinin-like protein-1 (VSNL-1) mRNA in HI cells was significantly higher than that in LI cells. We also observed that VSNL-1 was over-expressed in tumor specimens from patients with distant organ metastases compared with those without metastases. Furthermore, the invasive and proliferative phenotypes of neuroblastoma cells could be exchanged by regulation of VSNL-1 expression in vitro and in vivo. Up-regulation of VSNL-1 potentiated the anoikis-resistant ability of neuroblastoma cell. The expression of anoikis inhibitor TrkB, intracellular adhesion molecule 1, major histocompatibility complex class I, CD44 and CD44v6 was associated with VSNL-1 level. These results suggested that distinct roles of proliferative and invasive phenotypes contributed to neuroblastoma progression and strongly demonstrated that VSNL-1 played a very important role in neuroblastoma metastasis.

Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. Publishing Authors By Initials

Y Xie,H Chan,J Fan,Y Chen,J Young,W Li,X Miao,Z Yuan,H Wang,PK Tam,Y Ren,Y Xie,H Chan,J Fan,Y Chen,J Young,W Li,X Miao,Z Yuan,H Wang,PK Tam,Y Ren,Y Xie,H Chan,J Fan,Y Chen,J Young,W Li,X Miao,Z Yuan,H Wang,PK Tam,Y Ren,

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Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 2122-30

Journal Abbreviation: Carcinogenesis

ISSN: 1460-2180

DAY: 5

MONTH: 07

YEAR: 2007

Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. Information

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LANGUAGE: eng

NlmUniqueID: 8008055

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Grant and Affiliation Information for Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma.

AFFILIATION: Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.

Country: England

AGENCY: United States NIGMS

GRANT: R01-GM072611

ACRONYM: GM

MEDLINETA: Carcinogenesis

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