Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers.

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Abstract Text:

PURPOSE: To examine the mechanisms of the alteration of serum uric acid level by angiotensin II receptor blockers (ARBs), the effects of ARBs on renal uric acid transporters, including OAT1, OAT3, OAT4, and MRP4, were evaluated. MATERIALS AND METHODS: Uptakes of uric acid by OAT1-expressing Flp293 cells, by Xenopus oocytes expressing OAT3 or OAT4, and by membrane vesicles from Sf9 cells expressing MRP4 were evaluated in the presence or absence of ARBs. RESULTS: All ARBs inhibited uptake of uric acid or estrone-3-sulfate by OAT1, OAT3 and OAT4 in concentration dependent manners. Among them, the IC(50) values of valsartan, olmesartan and pratosartan for OAT3 were comparable to clinically observed unbound maximum plasma concentration of ARBs. Candesartan, losartan, and telmisartan inhibited ATP-dependent uptake of uric acid by MRP4 at 10 muM. The IC(50) value of losartan for MRP4 was comparable to the estimated kidney tissue concentration of losartan. No ARBs showed trans-stimulatory effects on the uptake of estrone-3-sulfate by OAT4. CONCLUSION: Valsartan, olmesartan, and pratosartan could inhibit the OAT3-mediated uric acid secretion in clinical situations. Furthermore losartan could inhibit ATP-dependent uric acid secretion by MRP4. These effects may explain partially the alteration of serum uric acid level by ARBs.

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutical research

VOLUME: 25

Page Numbers: 639-46

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 3

MONTH: 08

YEAR: 2007

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406521

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers.

AFFILIATION: Department of Membrane Transport and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba, 278-8510, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharm Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers Related Publications

• A novel fucosylated glycosphingolipid with a Gal beta 1-4Glc beta 1-3Gal sequence in plerocercoids of the parasite, Spirometra erinacei.
• Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation.
• Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation.
• BDNF increases the phagocytic activity in cultured iris pigment epithelial cells.
• Calcium ion dependent interaction of inorganic phosphorus compounds with phosphatidylcholine.
• Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells.
• Edaravone prevents kainic acid-induced neuronal death.
• Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver.
• Evidence of alpha-adrenoceptor-mediated chronotropic action in children.
• Expression of glycerol 3-phosphate dehydrogenase gene (CvGPD1) in salt-tolerant yeast Candida versatilis is stimulated by high concentrations of NaCl.
• Heterologous expression of Na+/H+ antiporter gene (CvNHA1) from salt-tolerant yeast Candida versatilis in Saccharomyces cerevisiae Na+-transporter deficient mutants.
• Influence of hospitalization on drug therapy in the elderly.
• Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers.
• Involvement of organic anion transporting polypeptide 1a5 (oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.
• Isolation of a subclonal cell line of PC12 transfected with dexamethasone-regulated ras oncogene: morphological differentiation, biochemical properties, and tumorigenicity.
• Isomerization of 11-cis-retinol to all-trans-retinol in bovine rod outer segments.
• Lengthening of short great toes by callus distraction.
• Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epithelium.
• Malunited fractures of the distal radius treated with corrective osteotomy using volar locking plate and a corticocancellous bone graft following immediate mobilisation.
• Molecular cloning and sequencing of plasma membrane H(+)-ATPase gene from the salt-tolerant yeast Zygosaccharomyces rouxii.
• Persistent posterolateral rotatory subluxation of the elbow in cubitus varus: a case report.
• Predominant Contribution of Rat Organic Anion Transporting Polypeptide-2 (Oatp2) to Hepatic Uptake of beta-Lactam Antibiotics.
• Presence and connections of auditory neurons in the rostrodorsal and rostrolateral parts of the thalamic reticular nucleus.
• Purification and some properties of membrane-bound phospholipase B from Torulaspora delbrueckii.
• Subtalar arthrography in acute injuries of the calcaneofibular ligament.
• Tarsal tunnel syndrome. Causes and results of operative treatment.
• Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine.
• Variant autonomic regulation during active standing in Swedish and Japanese junior high school children.
• [A case of bilateral synchronous primary lung cancer treated by two-staged bilateral bronchoplastic procedures]
• [Prognosis and therapy of adult acute leukemia with 11q23 abnormalities]