Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin.

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Research Abstract Details 

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Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Abstract Text:

Maria H Lymberopoulos,Angela Pearson,

UL24 of herpes simplex virus 1 is important for efficient viral replication, but its function is unknown. We generated a recombinant virus, vHA-UL24, encoding UL24 with an N-terminal hemagglutinin tag. By indirect immunofluorescence at 9 h post-infection (hpi), we detected HA-UL24 in nuclear foci and in cytoplasmic speckles. HA-UL24 partially co-localized with nucleolin, but not with ICP8 or coilin, markers for nucleoli, viral replication compartments, and Cajal bodies respectively. HA-UL24 staining was often juxtaposed to that of another nucleolar protein, fibrillarin. Analysis of HSV-1-induced nucleolar modifications revealed that by 18 hpi, nucleolin staining had dispersed, and fibrillarin staining went from clusters of small spots to a few separate but prominent spots. Fibrillarin redistribution appeared to be independent of UL24. In contrast, cells infected with a UL24-deficient virus retained foci of nucleolin staining. Our results demonstrate involvement of UL24 in dispersal of nucleolin during infection.

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Publishing Authors By Initials

MH Lymberopoulos,A Pearson,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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MEDLINE DATE:

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Virology

VOLUME: 363

Page Numbers: 397-409

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 7

MONTH: 03

YEAR: 2007

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Information

Substance Name: nucleolin

Registry Number: 0

Grant and Affiliation Information for Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin.

AFFILIATION: INRS-Institut Armand-Frappier, Université du Québec, 531 boul. des Prairies, Laval, Québec, Canada H7V 1B7. maria.lymberopoulos@iaf.inrs.ca <maria.lymberopoulos@iaf.inrs.ca>

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI26126

ACRONYM: AI

MEDLINETA: Virology

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