Involvement of the Gab2 scaffolding adapter in type I interferon signalling.

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Abstract Text:

Florence Baychelier,Pierre-Claude Nardeux,Chantal Cajean-Feroldi,Myriam Ermonval,Jacqueline Guymarho, Tovey,Pierre Eid,Florence Baychelier,Pierre-Claude Nardeux,Chantal Cajean-Feroldi,Myriam Ermonval,Jacqueline Guymarho, Tovey,Pierre Eid,

Interferons (IFNs) are pleiotropic cytokines involved in the regulation of physiological and pathological processes. Upon interaction with their specific receptors, IFNs activate the Jak/STAT signalling pathway. Numerous studies suggest, however, that the classical Jak/STAT pathway cannot alone account for the wide range of IFN's biological effects. To better understand the role of alternative signalling pathways in the type I IFNs response, we analyzed novel tyrosine-phosphorylated proteins following IFN-alpha2 stimulation. We showed for the first time that the Grb2-associated binder 2 (Gab2) protein is differentially phosphorylated upon the IFN subtype employed and the cells stimulated. We demonstrated that IFNAR1 physically interacts with Gab2. Moreover, the cellular content of Gab2 varies as a function of IFN receptor chain expression levels, and in particular of the ratio of IFNAR1 to IFNAR2, suggesting that Gab2 and IFNAR2 compete for interaction with IFNAR1. Analysis of Gab2 deletion mutants indicates that IFNAR1 might interact with a Gab2 region containing p85-PI3'kinase binding sites. Our results shed new light on recent data involving both Gab2 and type I IFNs in osteoclastogenesis and oncogenesis.

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Publishing Authors By Initials

F Baychelier,PC Nardeux,C Cajean-Feroldi,M Ermonval,J Guymarho,MG Tovey,P Eid,F Baychelier,PC Nardeux,C Cajean-Feroldi,M Ermonval,J Guymarho,MG Tovey,P Eid,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular signalling

VOLUME: 19

Page Numbers: 2080-7

Journal Abbreviation: Cell. Signal.

ISSN: 0898-6568

DAY: 9

MONTH: 06

YEAR: 2007

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904683

Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Involvement of the Gab2 scaffolding adapter in type I interferon signalling.

AFFILIATION: Laboratoire d'Oncologie virale, CNRS FRE 2937, 7 rue Guy Moquet, 94801 Villejuif, France.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Signal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of the Gab2 scaffolding adapter in type I interferon signalling Related Publications

• A simple method for the treatment of fractures of the shaft of the humerus.
• Acute haematogenous osteomyelitis and ABO blood groups and secretor status.
• Antimicrobial activity of acrylic intraocular lenses soaked in fourth generation fluoroquinolones.
• Caseous lymphadenitis of sheep and goats in Nigeria.
• Combined viscocanalostomy-trabeculectomy for management of far-advanced glaucoma: evaluation of the early postoperative course.
• Congenital segmental dilatation of the small bowel (CSD).
• Considerations regarding the present and future roles of colonoscopy in colorectal cancer prevention.
• Construction of intrauterine growth curves in a high altitude area of Saudi Arabia.
• DC-Dielectrophoretic separation of biological cells by size.
• Early urinary complications of fractures of the pelvis.
• Follow-up study of physical growth of children who had excessive weight gain in first six months of life.
• Gastroenterologist-directed propofol: an update.
• Gastroesophageal reflux is a major cause of lung disease-pro.
• Hypoplasia of lung with congenital diaphragmatic hernia.
• Incidence and importance of chronic mastitis in Nigeria goats.
• Involvement of the Gab2 scaffolding adapter in type I interferon signalling.
• Kinetic spectrophotometric method for the determination of ranitidine and nizatidine in pharmaceuticals.
• Laparoscopic colorectal surgery is safe in the high-risk patient: a NSQIP risk-adjusted analysis.
• Non-operative treatment of large anterior glenoid rim fractures after traumatic anterior dislocation of the shoulder.
• Non-urogenital abdominal complications associated with fractures of the pelvis.
• Skin disorders among male schoolchildren in the Asir region, southwestern Saudi Arabia.
• The effect of constant threat of terror on Israeli Jewish and Arab adolescents.
• The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.
• Voltammetric determination of nitrosocimetidine in simulated gastric juice.
• [Crotamiton (Eurax) as a mosquito repellent]