Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility.

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Abstract Text:

Zhong-Zong Pan,Wendy Bruening,Andrew K Godwin,

Synuclein-gamma is aberrantly expressed in more than 70% of stage III/IV breast and ovarian carcinomas. Ectopic overexpression of synuclein-gamma enhanced MDA-MB-435 cell migration in vitro and metastasis in a nude mouse model. However, the mechanism of how synuclein-gamma promotes cell motility is not clear. In our previous studies, we showed that synuclein-gamma overexpression activates ERK. In the present study, we overexpressed synuclein-gamma in several breast and ovarian cancer cell lines and evaluated the effect of synuclein-gamma on the activity of small G-protein RHO family members. We found that at least one of the RHO/RAC/CDC42 GTPases showed a higher level of the GTP-bound active form. Consistent with their role in regulating the intracellular motile machinery, inhibition of the RHO/RAC/CDC42 by C. difficile Toxin B blocked cell migration in both parental cells and synuclein-gamma overexpressing cells. The ERK inhibitor U0126 also blocked the cell migration in both parental cells and synuclein-gamma overexpressing cells. Collectively, our data indicate that synuclein-gamma might be involved in late stage breast and ovarian cancer metastasis by enhancing cell motility through activation of the RHO family small-GTPases and ERK.

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Publishing Authors By Initials

ZZ Pan,W Bruening,AK Godwin,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of oncology

VOLUME: 29

Page Numbers: 1201-5

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 3

MONTH: Nov

YEAR: 2006

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9306042

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Keywords Mesh Terms:

KEYWORDS: rho GTP-Binding Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Information

Substance Name: rho GTP-Binding Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility.

AFFILIATION: Department of Animal Science, University of Vermont, Burlington, VT 05405, USA. zpan@uvm.edu

Country: Greece

AGENCY: United States NCI

GRANT: P50 CA83638

ACRONYM: CA

MEDLINETA: Int J Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility Related Publications

• 18F FDG-PET/CT findings in recurrent respiratory papillomatosis.
• Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk.
• Aromatase immunoreactivity in the bluehead wrasse brain, Thalassoma bifasciatum: immunolocalization and co-regionalization with arginine vasotocin and tyrosine hydroxylase.
• BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance.
• Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration.
• Calcified pulmonary nodules in chronic renal failure.
• Characterization of the first N2S(alkylthiolate)lead compound: a model for three-coordinate lead in biological systems.
• Community action for preventing HIV in Cambodia: evaluation of a 3-year project.
• Continuous, intermittent and passive sampling of airborne VOCs.
• Cortical feedback to the thalamus is selectively enhanced by nitric oxide.
• Evidence-based educational guidelines for stroke survivors after discharge home.
• Extrapleural fat collections: pseudotumors and other confusing manifestations.
• Follicular hyperplasia of bronchus-associated lymphoid tissue causing severe air trapping.
• Hydroxyurea (NSC-32065) intermittent therapy in malignant diseases.
• Inspiratory and expiratory high-resolution CT findings in a patient with Sjögren's syndrome and cystic lung disease.
• Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.
• Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility.
• Memantine: the next trend in academic performance enhancement?
• Motion artifacts on CT simulate bronchiectasis.
• Occurrence of Listeria and Enterobacteriaceae in domestic refrigerators.
• On the estimation of dispersion by linear systematic statistics.
• Pneumomediastinum: old signs and new signs.
• Respiratory compensation in projection imaging using a magnification and displacement model.
• Simplified plain film screening examination for erosive otitis media.
• Some aspects of bladder cancer.
• Some aspects of bladder cancer.
• Surgical defects of the pericardium: radiographic findings.
• The molecular pathogenesis of gastrointestinal stromal tumors.
• The obscured outer edge: a sign of improperly placed pleural drainage tubes.
• VOC and particulate emissions from commercial cigarettes: analysis of 2,5-DMF as an ETS tracer.