Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Research Abstract Details 

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Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Abstract Text:

Shin-ichiro Kina,Tohru Tezuka,Shinji Kusakawa,Yasushi Kishimoto,Sho Kakizawa,Koichi Hashimoto,Miho Ohsugi,Yuji Kiyama,Reiko Horai,Katsuko Sudo,Shigeru Kakuta,Yoichiro Iwakura,Masamitsu Iino,Masanobu Kano,Toshiya Manabe,Tadashi Yamamoto,Shin-ichiro Kina,Tohru Tezuka,Shinji Kusakawa,Yasushi Kishimoto,Sho Kakizawa,Koichi Hashimoto,Miho Ohsugi,Yuji Kiyama,Reiko Horai,Katsuko Sudo,Shigeru Kakuta,Yoichiro Iwakura,Masamitsu Iino,Masanobu Kano,Toshiya Manabe,Tadashi Yamamoto,

Although protein-tyrosine phosphorylation is important for hippocampus-dependent learning, its role in cerebellum-dependent learning remains unclear. We previously found that PTPMEG, a cytoplasmic protein-tyrosine phosphatase expressed in Purkinje cells (PCs), bound to the carboxyl-terminus of the glutamate receptor delta2 via the postsynaptic density-95/discs-large/ZO-1 domain of PTPMEG. In the present study, we generated PTPMEG-knockout (KO) mice, and addressed whether PTPMEG is involved in cerebellar plasticity and cerebellum-dependent learning. The structure of the cerebellum in PTPMEG-KO mice appeared grossly normal. However, we found that PTPMEG-KO mice showed severe impairment in the accelerated rotarod test. These mice also exhibited impairment in rapid acquisition of the cerebellum-dependent delay eyeblink conditioning, in which conditioned stimulus (450-ms tone) and unconditioned stimulus (100-ms periorbital electrical shock) were co-terminated. Moreover, long-term depression at parallel fiber-PC synapses was significantly attenuated in these mice. Developmental elimination of surplus climbing fibers and the physiological properties of excitatory synaptic inputs to PCs appeared normal in PTPMEG-KO mice. These results suggest that tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity.

Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Publishing Authors By Initials

S Kina,T Tezuka,S Kusakawa,Y Kishimoto,S Kakizawa,K Hashimoto,M Ohsugi,Y Kiyama,R Horai,K Sudo,S Kakuta,Y Iwakura,M Iino,M Kano,T Manabe,T Yamamoto,S Kina,T Tezuka,S Kusakawa,Y Kishimoto,S Kakizawa,K Hashimoto,M Ohsugi,Y Kiyama,R Horai,K Sudo,S Kakuta,Y Iwakura,M Iino,M Kano,T Manabe,T Yamamoto,

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Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 26

Page Numbers: 2269-78

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 23

MONTH: Oct

YEAR: 2007

Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

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Grant and Affiliation Information for Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

AFFILIATION: Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.

Country: France

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MEDLINETA: Eur J Neurosci

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