Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.

Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. Research Abstract Details 

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Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. Abstract Text:

H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,

We investigated the roles of cyclooxygenase (COX) isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion in the damaged mouse stomach. Male C57/BL6 mice, both wild type and animals lacking EP1, EP3, or IP receptors, were used after 18 h of fasting. Under urethane anesthesia, the stomach was mounted on an ex-vivo chamber and perfused with saline, and acid secretion as well as transmucosal potential difference (PD) was measured before and after exposure to 20 mM taurocholate Na (TC) for 20 min. Indomethacin, SC-560 or rofecoxib was given i.d. 30 min before TC. Mucosal exposure to TC in wild-type mice caused a reduction in PD, followed by decrease in acid secretion. Indomethacin attenuated the decrease in acid secretion after exposure to TC in wild-type mice, an effect mimicked by SC-560 but not rofecoxib, yet none of these drugs affected the decrease in PD. An altered acid response after exposure to TC was similarly observed in EP1 (-/-) mice but mitigated in mice lacking either EP3 or IP receptors, although a decrease in PD was observed in all groups. Furthermore, the decreased acid response was also attenuated by prior administration of the EP3- but not EP1- antagonist. Mucosal levels of PGE(2) and 6-keto PGF(1a) increased after exposure to TC in all groups of mice. In conclusion, the decrease in acid secretion in the damaged stomach is mediated by endogenous PGs derived from COX-1, through PGE(2)/EP3 receptors and prostacyclin/IP receptors.

Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. Publishing Authors By Initials

H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,H Nishio,S Terashima,M Nakashima,E Aihara,K Takeuchi,

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Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of physiology and pharmacology : an offici

VOLUME: 58

Page Numbers: 407-21

Journal Abbreviation: J. Physiol. Pharmacol.

ISSN: 0867-5910

DAY: 11

MONTH: Sep

YEAR: 2007

Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. Information

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LANGUAGE: eng

NlmUniqueID: 9114501

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Grant and Affiliation Information for Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.

AFFILIATION: Department of Pharmacology and Experimental Therapeutic, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, Japan.

Country: Poland

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MEDLINETA: J Physiol Pharmacol

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