Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa.

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Abstract Text:

T G Cooper,C H Yeung,T G Cooper,C H Yeung,

Spermatozoa produced in the testis undergo maturation in the epididymis which secretes an osmolyte-rich fluid that bathes the sperm cells. These cells need to maintain their volume after ejaculation when they first encounter hypo-osmolal environments of accessory gland fluids and later within the female tract. If they do not, they experience swelling that is manifested in flagellar angulation that prevents their passage through cervical mucus or the uterotubal junction and they never reach the oocytes. This is a cause of male infertility in domestic species and certain infertile transgenic mice in which flagellar angulation has been shown to indicate cell swelling as a consequence of reduced epididymal provision of osmolytes. The reduced volume regulating ability of spermatozoa from subfertile boars and bulls has prompted study of volume regulation of spermatozoa as a possible cause of human male infertility. Understanding this process may make its manipulation possible and could suggest better sperm handling and storage techniques and thus provide therapy for infertile patients. On the other hand, volume regulation is a potential target for contraception if mimicking the conditions expressed by the "sterile studs" were possible. The evidence for the presence of ion channels probably responsible for regulatory volume decreases in spermatozoa is reviewed here that implicate voltage-gated potassium channels (especially Kv1.5 (KCNA5), minK (KCNE1) and TASK2 (KCNK5)) and the chloride channels CLCN3 and CLNS1A. The involvement of ion co-transporters in volume regulation of spermatozoa is also discussed.

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Publishing Authors By Initials

TG Cooper,CH Yeung,TG Cooper,CH Yeung,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current pharmaceutical design

VOLUME: 13

Page Numbers: 3222-30

Journal Abbreviation: Curr. Pharm. Des.

ISSN: 1873-4286

DAY: 29

MONTH: 11

YEAR: 2007

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9602487

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa.

AFFILIATION: Institute of Reproductive Medicine of the University, Domagkstrasse 11, D-48129 Münster, Germany. TrevorG.Cooper@ukmuenster.de

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Curr Pharm Des

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa Related Publications

• A handheld device for potential point-of-care screening of cancer.
• A hypothesis: Sunspot cycles may detect pandemic influenza A in 1700-2000 A.D.
• Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms.
• Angle-insensitive flow measurement using Doppler bandwidth.
• Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.
• Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.
• Eagle eyes.
• Familial extrarenal Wilms tumor.
• Fluoride prevents caries among adults of all ages.
• Homonuclear broad-band-decoupled chemical shift imaging by singular value decomposition with optimization.
• Influence and adjustment goals: sources of cultural differences in ideal affect.
• Involvement of potassium and chloride channels and other transporters in volume regulation by spermatozoa.
• Lithium overdose causing non-convulsive status epilepticus--the importance of lithium levels and the electroencephalography in diagnosis.
• Mechanisms of the vasorelaxant effect of 1, 5-dihydroxy-2, 3-dimethoxy-xanthone, an active metabolite of 1-hydroxy-2, 3, 5-trimethoxy-xanthone isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery.
• Minimal invasive surgery in pediatric solid tumors.
• New detection schemes in liquid chromatography.
• Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis.
• Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction.
• Quantitative imaging of gene expression in individual bacterial cells by chemiluminescence.
• Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection.
• Searchable high-resolution 2D gel proteome of the human colon crypt.
• Sensitivity analysis of multilayer perceptron to input and weight perturbations.
• Single-molecule detection of surface-hybridized human papilloma virus DNA for quantitative clinical screening.
• Single-molecule reactions in liposomes.
• Suanzaorentang and serotonin syndrome.
• Tuning certainty factor and local weight of fuzzy production rules by using fuzzy neural network.
• [Effect of human oviductal embryotrophic factors on gene expression of mouse preimplantation embryos.]
• [In Process Citation]
• [In Process Citation]
• [In Process Citation]