Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Research Abstract Details 

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Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Abstract Text:

Yasuo Takamune,Tetsuro Ikebe,Osamu Nagano,Masanori Shinohara,Yasuo Takamune,Tetsuro Ikebe,Osamu Nagano,Masanori Shinohara,

The involvement of a disintegrin and metalloprotease domain (ADAM)-17 on the cancer invasion was investigated in oral squamous cell carcinoma (OSCC) cells. TNFalpha induced the conversion from the proform of ADAM-17 to its mature form time-dependently. TNFalpha also cleaved CD44 to its small fragments, as observed by a Western blot analysis. The transfection of ADAM-17 siRNA partially suppressed the expression of ADAM-17 as well as the cleavage of CD44. On the other hand, TNFalpha activated a transcription factor NF-kappaB in OSCC cells, while NBD peptide, an NF-kappaB inhibitor, inhibited the ADAM-17 maturation, thus suggesting that NF-kappaB is involved in ADAM-17 maturation. Moreover, an in vitro invasion assay revealed that both ADAM-17 siRNA and NBD peptides strongly suppressed the TNFalpha-induced invasion of OSCC cells through the matrix. In conclusion, ADAM-17 plays an important role in cancer invasion probably through CD44 cleavage.

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Publishing Authors By Initials

Y Takamune,T Ikebe,O Nagano,M Shinohara,Y Takamune,T Ikebe,O Nagano,M Shinohara,

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Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 365

Page Numbers: 393-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 20

MONTH: 11

YEAR: 2007

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.

AFFILIATION: Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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