Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats.

Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. Research Abstract Details 

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Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. Abstract Text:

Hajime Taniguchi,Ryoji Kojima,Hiroko Sade,Mayumi Furuya,Norio Inomata,Mikio Ito,Hajime Taniguchi,Ryoji Kojima,Hiroko Sade,Mayumi Furuya,Norio Inomata,Mikio Ito,

We investigated participation of monocyte chemoattractant protein-1 (MCP-1) in tubulointerstitial fibrosis and correlation between MCP-1 and proteinuria in Wistar-Kyoto (WKY) rats with glomerulonephritis induced by anti-glomerular basement membrane (anti-GBM) antibody. WKY rats showed marked proteinuria and severe glomerular crescent formation at 7 days post antibody injection. At 28 days, tubulointerstitial fibrotic lesions were observed, followed by sustained heavy proteinuria and severe tubulointerstitial fibrosis at 56 days. Histological examination revealed that the overlapped immunoreactivities of MCP-1, rat albumin, and p65NF-kappaB were detected in the same tubular segments of nephritic kidney, and a significant positive correlation was observed between proteinuria and MCP-1 expression in the tubulointerstitial fibrosis. ED-1- and CD8-positive cells were also abundant, and there was a good correlation between monocyte/macrophage recruitment and MCP-1 expression in the tubulointerstitial area. These results suggest that MCP-1 participates in the progression of tubulointerstitial fibrosis, through massive albuminuria, which is accompanied by marked monocyte/macrophage recruitment.

Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. Publishing Authors By Initials

H Taniguchi,R Kojima,H Sade,M Furuya,N Inomata,M Ito,H Taniguchi,R Kojima,H Sade,M Furuya,N Inomata,M Ito,

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Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical immunology

VOLUME: 27

Page Numbers: 409-29

Journal Abbreviation: J. Clin. Immunol.

ISSN: 0271-9142

DAY: 22

MONTH: 05

YEAR: 2007

Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. Information

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LANGUAGE: eng

NlmUniqueID: 8102137

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Grant and Affiliation Information for Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats.

AFFILIATION: Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd., Osaka, Japan.

Country: United States

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MEDLINETA: J Clin Immunol

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