Involvement of homeobox genes in Mammalian sexual development.

Involvement of homeobox genes in Mammalian sexual development. Research Abstract Details 

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Involvement of homeobox genes in Mammalian sexual development. Abstract Text:

In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a complex network of morphogenetic signals, many of which are still uncharacterised. Homeobox genes are known to play important roles in embryo morphogenesis and organogenesis in a number of systems. Here, we review current data relating to possible roles of the extended homeobox gene family on gonad development, sex-specific morphogenesis and gametogenesis, and speculate that these genes may play a broader role in these processes than is currently suspected. Copyright (c) 2007 S. Karger AG, Basel.

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Involvement of homeobox genes in Mammalian sexual development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sexual development : genetics, molecular biology,

VOLUME: 1

Page Numbers: 12-23

Journal Abbreviation: Sex Dev

ISSN: 1661-5433

DAY: 8

MONTH: 04

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Country: Switzerland

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MEDLINETA: Sex Dev

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