Involvement of glycation and oxidative stress in diabetic macroangiopathy.

Involvement of glycation and oxidative stress in diabetic macroangiopathy. Research Abstract Details 

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Involvement of glycation and oxidative stress in diabetic macroangiopathy. Abstract Text:

N Taniguchi,H Kaneto,M Asahi,M Takahashi,C Wenyi,S Higashiyama,J Fujii,K Suzuki,Y Kayanoki,

Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also thought to be involved in the pathogenesis of diabetic complications, including the progression of macroangiopathy. Proliferation of smooth muscle cells (SMCs) is known to be associated with progression of macroangiopathy and is modulated by several growth factors. At least three mitogens for SMCs, platelet-derived growth factor (PDGF), fibroblast growth factor, and heparin-binding epidermal growth factor-like growth factor (HB-EGF), are known to be produced by SMCs themselves and are considered to be the most potent growth factors in the progression of macroangiopathy as seen in diabetes. HB-EGF, but not PDGF, is regulated at the transcriptional level by 3-deoxyglucosone (3-DG), a major and highly reactive intermediate in the glycation reaction. The induction seems to be triggered by the increase of reactive oxygen species produced by 3-DG. Taken together, glycation reactions under diabetic conditions may be highly associated with the pathogenesis of diabetic macroangiography by enhancing the gene expression of HB-EGF.

Involvement of glycation and oxidative stress in diabetic macroangiopathy. Publishing Authors By Initials

N Taniguchi,H Kaneto,M Asahi,M Takahashi,C Wenyi,S Higashiyama,J Fujii,K Suzuki,Y Kayanoki,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Involvement of glycation and oxidative stress in diabetic macroangiopathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes

VOLUME: 45 Suppl 3

Page Numbers: S81-3

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 22

MONTH: Jul

YEAR: 1996

Involvement of glycation and oxidative stress in diabetic macroangiopathy. Information

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LANGUAGE: eng

NlmUniqueID: 372763

Involvement of glycation and oxidative stress in diabetic macroangiopathy. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: genetics

Chemical & Substance for Abstract: Involvement of glycation and oxidative stress in diabetic macroangiopathy. Information

Substance Name: Epidermal Growth Factor

Registry Number: 62229-50-9

Grant and Affiliation Information for Involvement of glycation and oxidative stress in diabetic macroangiopathy.

AFFILIATION: Department of Biochemistry, Osaka University Medical School, Japan.

Country: UNITED STATES

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MEDLINETA: Diabetes

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