Involvement of gamma-secretase in postnatal angiogenesis.

Involvement of gamma-secretase in postnatal angiogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of gamma-secretase in postnatal angiogenesis. Abstract Text:

Hiroki Hayashi,Hironori Nakagami,Yoichi Takami,Naoyuki Sato,Yukihiro Saito,Tomoyuki Nishikawa,Masaki Mori,Hiroshi Koriyama,Katsuto Tamai,Ryuichi Morishita,Yasufumi Kaneda,Hiroki Hayashi,Hironori Nakagami,Yoichi Takami,Naoyuki Sato,Yukihiro Saito,Tomoyuki Nishikawa,Masaki Mori,Hiroshi Koriyama,Katsuto Tamai,Ryuichi Morishita,Yasufumi Kaneda,Hiroki Hayashi,Hironori Nakagami,Yoichi Takami,Naoyuki Sato,Yukihiro Saito,Tomoyuki Nishikawa,Masaki Mori,Hiroshi Koriyama,Katsuto Tamai,Ryuichi Morishita,Yasufumi Kaneda,

gamma-Secretase cleaves the transmembrane domains of several integral membrane proteins involved in vasculogenesis. Here, we investigated the role of gamma-secretase in the regulation of postnatal angiogenesis using gamma-secretase inhibitors (GSI). In endothelial cell (EC), gamma-secretase activity was up-regulated under hypoxia or the treatment of vascular endothelial growth factor (VEGF). The treatment of GSI significantly attenuated growth factor-induced EC proliferation and migration as well as c-fos promoter activity in a dose-dependent manner. In vascular smooth muscle cell (VSMC), treatment of GSI significantly attenuated growth factor-induced VEGF and fibroblast growth factor-2 (FGF-2) expression. Indeed, GSI attenuated VEGF-induced tube formation and inhibited FGF-2-induced angiogenesis on matrigel in mice as quantified by FITC-lectin staining of EC. Overall, we demonstrated that gamma-secretase may be key molecule in postnatal angiogenesis which may be downstream molecule of growth factor-induced growth and migration in EC, and regulate the expression of angiogenic growth factors in VSMC.

Involvement of gamma-secretase in postnatal angiogenesis. Publishing Authors By Initials

H Hayashi,H Nakagami,Y Takami,N Sato,Y Saito,T Nishikawa,M Mori,H Koriyama,K Tamai,R Morishita,Y Kaneda,H Hayashi,H Nakagami,Y Takami,N Sato,Y Saito,T Nishikawa,M Mori,H Koriyama,K Tamai,R Morishita,Y Kaneda,H Hayashi,H Nakagami,Y Takami,N Sato,Y Saito,T Nishikawa,M Mori,H Koriyama,K Tamai,R Morishita,Y Kaneda,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of gamma-secretase in postnatal angiogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 584-90

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 14

MONTH: 09

YEAR: 2007

Involvement of gamma-secretase in postnatal angiogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Involvement of gamma-secretase in postnatal angiogenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Involvement of gamma-secretase in postnatal angiogenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Involvement of gamma-secretase in postnatal angiogenesis.

AFFILIATION: Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of gamma-secretase in postnatal angiogenesis Related Publications

• A novel montmorillonite-enwrapped scandium as a heterogeneous catalyst for Michael reaction.
• Amino acid sequence and some properties of phytolacain R, a cysteine protease from full-growth fruits of pokeweed, Phytolacca americana.
• Anticancer Immunotherapy using Inactivated Sendai Virus Particles.
• Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice.
• Chromosomal pericentric inversion detected in a sow and her piglets.
• Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway.
• Cleavage specificity of cucumisin, a plant serine protease.
• Complex roles of endothelial shear stress in vascular remodeling response.
• Determination of pepstatin-sensitive carboxyl proteases by using pepstatinyldansyldiaminopropane (dansyl-pepstatin) as an active site titrant.
• Development of a transferrin receptor-targeting HVJ-E vector.
• Development of tissue-targeting hemagglutinating virus of Japan envelope vector for successful delivery of therapeutic gene to mouse skin.
• Efficient transfer of intact oligonucleotides into the nucleus of ligament scar fibroblasts by HVJ-cationic liposomes is correlated with effective antisense gene inhibition.
• Functional modification of Sendai virus by siRNA.
• Identification of the reactive histidine of cucumisin, a plant serine protease: modification with peptidyl chloromethyl ketone derivative of peptide substrate.
• Intratumoral injection of inactivated Sendai virus particles elicits strong antitumor activity by enhancing local CXCL10 expression and systemic NK cell activation.
• Involvement of gamma-secretase in postnatal angiogenesis.
• Isolation and characterization of pepsinogen from Trimeresurus flavoviridis (Habu snake).
• Isolation and characterization of small nuclear RNAs from Dictyostelium discoideum.
• Needleless intranasal administration of HVJ-E containing allergen attenuates experimental allergic rhinitis.
• No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART.
• PAMAM dendron-stabilised palladium nanoparticles: effect of generation and peripheral groups on particle size and hydrogenation activity.
• Phospholipid hydroperoxide accumulation in liver of rats intoxicated with carbon tetrachloride and its inhibition by dietary alpha-tocopherol.
• Presence of phosphatidylcholine hydroperoxide in human plasma.
• Re: coronary plaque composition of culprit/target lesions according to the clinical presentation: a virtual histology intravascular ultrasound analysis.
• Reconstitution of chromatin in vitro.
• Unfolding of tetraplex structure of mouse telomeric DNA by the interaction with mouse telomeric DNA binding protein Pot1.
• Unusual behavior of CMC for binary mixtures of alkyltrimethylammonium bromides: dependence on chain length difference.
• Use of structure-controlled polymers as high performance powder dispersants in the silicone oil phase.
• [Study on the active life expectancy of the elderly and its longitudinal transition in Beijing]
• alpha-CD/crown-appended diazophenol for selective sensing of amines.