Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases.

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Abstract Text:

Guo-Xing Zhang,Yukiko Nagai,Toshitaka Nakagawa,Hiroshi Miyanaka,Yoshihide Fujisawa,Akira Nishiyama,Kunihiko Izuishi,Koji Ohmori,Shoji Kimura,Guo-Xing Zhang,Yukiko Nagai,Toshitaka Nakagawa,Hiroshi Miyanaka,Yoshihide Fujisawa,Akira Nishiyama,Kunihiko Izuishi,Koji Ohmori,Shoji Kimura,

Angiotensin II (ANG II) is a powerful activator of mitogen-activated protein (MAP) kinase cascades in cardiovascular tissues through a redox-sensitive mechanism. Nitric oxide (NO) is considered to antagonize the vasoconstrictive and proarteriosclerotic actions of ANG II. However, the role of endogenous NO in ANG II-induced redox-sensitive signal transduction is not yet clear. In this study using catheterized, conscious rats, we found that acute intravenous administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 5 mg/kg) enhanced phosphorylation of aortic MAP kinases extracellular signal regulated kinase (ERK) 1/2 and p38, which were suppressed only partially by a superoxide dismutase mimetic (Tempol), whereas ANG II-induced MAP kinase phosphorylation was markedly suppressed by Tempol. FK409, a NO donor, had little effect on vascular MAP kinase phosphorylation. On the other hand, acute exposure to a vasoconstrictor dose of ANG II (200 ng x kg(-1) x min(-1) iv) failed to enhance phosphorylation of aortic MAP kinases in the chronically L-NAME-treated rats, whereas the vasoconstrictor effect of ANG II was not affected by L-NAME treatment. Furthermore, three different inhibitors of NO synthase suppressed, in a dose-dependent manner, ANG II-induced MAP kinase phosphorylation in rat vascular smooth muscle cells, which was closely linked to superoxide generation in cells. These results indicate the involvement of endogenous NO synthase in ANG II-induced signaling pathways, leading to activation of MAP kinase, and that NO may have dual effects on the vascular MAP kinase activation associated with redox sensitivity.

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Publishing Authors By Initials

GX Zhang,Y Nagai,T Nakagawa,H Miyanaka,Y Fujisawa,A Nishiyama,K Izuishi,K Ohmori,S Kimura,GX Zhang,Y Nagai,T Nakagawa,H Miyanaka,Y Fujisawa,A Nishiyama,K Izuishi,K Ohmori,S Kimura,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Heart and circulat

VOLUME: 293

Page Numbers: H2403-8

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 6

MONTH: 07

YEAR: 2007

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901228

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Keywords Mesh Terms:

KEYWORDS: p38 Mitogen-Activated Protein Kinases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Information

Substance Name: p38 Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases.

AFFILIATION: Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Physiol Heart Circ Physio

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases Related Publications

• A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice.
• A phase I/II clinical trial of enzyme replacement therapy in mucopolysaccharidosis II (Hunter syndrome).
• A simple accurate method of alignment of beamline optics with the use of EUV multilayer polarizers.
• Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.
• Enhanced stereocomplex formation of poly(L-lactic acid) and poly(D-lactic acid) in the presence of stereoblock poly(lactic acid).
• Enhancing effect of medium-chain triglycerides on intestinal absorption of d-alpha-tocopherol acetate from lecithin-dispersed preparations in the rat.
• Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring.
• Expression of vascular endothelial growth factor by photodynamic therapy with mono-L-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma.
• Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus.
• Further investigations of enhancing effect of medium-chain triglycerides on d-alpha-tocopherol acetate absorption from lecithin-dispersed preparations in rat small intestine.
• Generalized grazing-incidence-angle X-ray diffraction (G-GIXD) using image plates.
• Human opioid peptide Met-enkephalin binds to anionic phosphatidylserine in high preference to zwitterionic phosphatidylcholine: natural-abundance 13C NMR study on the binding state in large unilamellar vesicles.
• Identification of nucleotide residues essential for RNase P activity from the hyperthermophilic archaeon Pyrococcus horikoshii OT3.
• Idiopathic spinal cord herniation. Report of two cases and review of the literature.
• Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from holstein cows.
• Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase.
• Interferon-gamma attenuates the survival activity of G-CSF through PI3K/Akt signaling pathway in mouse multipotent progenitor cells.
• Molecular mechanism of dysfunctional factor VII associated with the homozygous missense mutation 331Gly to Ser.
• Mycotic aneurysm of the right coronary artery.
• Paradoxical brain embolism may not be uncommon-prospective study in acute ischemic stroke.
• Prevalence of coinfection with human immunodeficiency virus and hepatitis C virus in Japan.
• Structural analysis of obscurin gene in hypertrophic cardiomyopathy.
• Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure.
• Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.
• [In Process Citation]
• [In Process Citation]
• [MicroRNAs: novel class of gene regulators involved in endocrine function and cancer]
• [Polymorphism on codon 98 of the galectin-3 gene are not associated to benign and malignant thyroid tumors]
• [Thermal expansion of layering porcelains for the tetragonal stabilized zirconia]
• [Tocopherol Acetate Reference Standard (Control 881) of National Institute of Hygienic Sciences]