Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae.

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Abstract Text:

Hiroshi Yokoyama,Masaki Mizunuma,Michiyo Okamoto,Josuke Yamamoto,Dai Hirata,Tokichi Miyakawa,

The Ca2+-activated pathways in Saccharomyces cerevisiae induce a delay in the onset of mitosis through the activation of Swe1p, a negative regulatory kinase that inhibits the Cdc28p/Clb complex. We isolated the YAP1 gene as a multicopy suppressor of calcium sensitivity owing to the loss of ZDS1, a negative regulator of SWE1 and CLN2 gene expression. YAP1 deletion on a zds1delta background exacerbated the Ca2+-related phenotype. Yap1p was degraded in a calcineurin-dependent manner when cells were exposed to calcium. In yap1delta cells, the expression level of the RPN4 gene encoding a transcription factor for the subunits of the ubiquitin-proteasome system was diminished. The deletion of YAP1 gene or RPN4 gene led to the accumulation of Swe1p and Cln2p. Yap1p was a substrate of calcineurin in vivo and in vitro. The calcineurin-mediated Yap1p degradation seems to be a long adaptive response that assures a G2 delay in response to a stress that causes the activation of the calcium signalling pathways.

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Publishing Authors By Initials

H Yokoyama,M Mizunuma,M Okamoto,J Yamamoto,D Hirata,T Miyakawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: EMBO reports

VOLUME: 7

Page Numbers: 519-24

Journal Abbreviation: EMBO Rep.

ISSN: 1469-221X

DAY: 17

MONTH: 02

YEAR: 2006

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100963049

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae.

AFFILIATION: Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima 739-8530, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: EMBO Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae Related Publications

• A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons.
• Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
• Array-enhanced coherence resonance and phase synchronization in a two-dimensional array of excitable chemical oscillators.
• Combined preoperative embolization of the right portal vein and hepatic artery for hepatic resection in a high-risk patient.
• Dementia and Borna disease virus.
• Development of EOG-Based Communication System Controlled by Eight-Directional Eye Movements.
• Evaluation of the preset travel routes in a self-determination support system.
• Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients.
• Identification of Saccharomyces cerevisiae Tub1 alpha-tubulin as a potential target for NKH-7, a cytotoxic 1-naphthol derivative compound.
• Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress.
• Inhibition of Ca2+-signal-dependent growth regulation by radicicol in budding yeast.
• Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes.
• Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae.
• Ionic strength and pH effects on the rates of reduction of spinach plastocyanin by ascorbate.
• Multislice CT study of pancreatic head arterial dominance.
• Pancreatoduodenectomy in which dissection of the efferent arteries of the head of the pancreas is performed first.
• Pneumatosis intestinalis and hepatic portal venous gas.
• Purification and properties of trehalase from rat intestinal mucosal cells.
• Structured neural network of medical diagnosis for hepatobiliary diseases.
• The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis.
• The role of hepatectomy for patients with liver metastases of gastric cancer.
• [Experimental animal models of multiple myeloma]
• [Investigating genes-to-behaviors pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice]
• [Navigation surgery for pancreatic disease using multislice computed tomography]
• [The effects of thyrotropin-suppressive therapy in patients with well-differentiated thyroid carcinoma]