Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.

Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Research Abstract Details 

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Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Abstract Text:

Wei Wang,Qinglong Guo,Qidong You,Kun Zhang,Yong Yang,Jun Yu,Wei Liu,Li Zhao,Hongyan Gu,Yang Hu,Zi Tan,Xiaotang Wang,

The molecular mechanisms of wogonin-induced apoptosis of human hepatoma SMMC-7721 cells are reported. Wogonin treatment resulted in significant inhibition of SMMC-7721 cells in a time-dependent and concentration-dependent manner. Typical morphological changes and apoptotic blebbing in SMMC-7721 cells were observed after treatment with 1x10(-4) mol/l wogonin for a period of 0-48 h. Flow cytometry and Annexin-V/propidium iodide double-staining experiments revealed a dramatic increase in the number of apoptotic and G0/G1 phase cells after wogonin treatment. The proapoptotic activity of wogonin is attributed to its ability to modulate the expression of bcl-2 and bax proteins. It is observed that the expression of bax protein is dramatically increased whereas the synthesis of bc1-2 protein is significantly decreased when cells are treated with wogonin. The results presented in this paper suggested an important relationship between gene regulation and wogonin-induced apoptosis, and indicated the possibility of developing naturally occurring monoflavonoids as novel anticancer agents for better management of human cancers.

Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Publishing Authors By Initials

W Wang,Q Guo,Q You,K Zhang,Y Yang,J Yu,W Liu,L Zhao,H Gu,Y Hu,Z Tan,X Wang,

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Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anti-cancer drugs

VOLUME: 17

Page Numbers: 797-805

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ISSN: 0959-4973

DAY: 3

MONTH: Aug

YEAR: 2006

Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Information

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LANGUAGE: eng

NlmUniqueID: 9100823

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Grant and Affiliation Information for Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.

AFFILIATION: Department of Physiology, China Pharmaceutical University, Nanjing, PRC.

Country: England

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MEDLINETA: Anticancer Drugs

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