Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans.

Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Research Abstract Details 

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Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Abstract Text:

Tejpratap S P Tiwari,Anne Golaz,Diana T Yu,Kristen R Ehresmann,Timothy F Jones,Hal E Hill,Pamela K Cassiday,Lucia C Pawloski,John S Moran,Tanja Popovic,Melinda Wharton,

BACKGROUND: We present 2 case reports in the United States and investigations of diphtheria-like illness caused by toxigenic Corynebacterium ulcerans. A fatal case occurred in a 75-year-old male Washington resident who was treated with clindamycin but did not receive equine diphtheria antitoxin. A second, nonfatal case occurred in a 66-year-old female Tennessee resident who received erythromycin and diphtheria antitoxin. METHODS: Both case patients and close human and animal contacts were investigated by their respective state health departments. RESULTS: C. ulcerans isolated from the patient who died was resistant to erythromycin and clindamycin. For both isolates, conventional polymerase chain reaction results were positive for A and B subunits of diphtheria toxin gene tox, and modified Elek tests confirmed toxin production. The source of infection remained undetermined for both cases. Neither patient was up-to-date with diphtheria toxoid vaccination. CONCLUSION: These case reports highlight the importance of early treatment with diphtheria antitoxin, the selection of effective antimicrobial agents, and prevention through up-to-date vaccination.

Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Publishing Authors By Initials

TS Tiwari,A Golaz,DT Yu,KR Ehresmann,TF Jones,HE Hill,PK Cassiday,LC Pawloski,JS Moran,T Popovic,M Wharton,

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Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical infectious diseases : an official publica

VOLUME: 46

Page Numbers: 395-401

Journal Abbreviation: Clin. Infect. Dis.

ISSN: 1537-6591

DAY: 1

MONTH: Feb

YEAR: 2008

Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Information

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LANGUAGE: eng

NlmUniqueID: 9203213

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AFFILIATION: Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. tit2@cdc.gov

Country: United States

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MEDLINETA: Clin Infect Dis

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