Investigating the functional role of CD2BP2 in T cells.

Investigating the functional role of CD2BP2 in T cells. Research Abstract Details 

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Investigating the functional role of CD2BP2 in T cells. Abstract Text:

Matthias Heinze,Michael Kofler,Christian Freund,Matthias Heinze,Michael Kofler,Christian Freund,Matthias Heinze,Michael Kofler,Christian Freund,

The adaptor protein CD2-binding protein 2 (CD2BP2) confers binding to proline-rich sequences (PRS) via its GYF domain. In addition to the cytoplasmic domain of CD2, several other proteins were identified as interaction partners of CD2BP2, but the in vivo significance of these findings is unclear. We now show that CD2BP2's nuclear localization is not changed when CD2 and CD2BP2 are co-expressed in HeLa cells, indicating that other PRS compete effectively for CD2BP2 binding in the nucleus. Since the CD2BP2-binding motifs of CD2 are known to be involved in cytokine signaling, we tested the effect of CD2BP2 knockdown in PBMCs on the expression of T-cell cytokines. No major difference in cytokine expression can be observed for primary cells transfected with CD2BP2-specific small interfering RNA. We conclude that CD2 signaling is at least partially independent of its in vitro binding partner CD2BP2.

Investigating the functional role of CD2BP2 in T cells. Publishing Authors By Initials

M Heinze,M Kofler,C Freund,M Heinze,M Kofler,C Freund,M Heinze,M Kofler,C Freund,

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Investigating the functional role of CD2BP2 in T cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunology

VOLUME: 19

Page Numbers: 1313-8

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 29

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Protein Engineering Group, Leibniz-Institute of Molecular Pharmacology and Free University Berlin, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

Country: England

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MEDLINETA: Int Immunol

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