Intrinsic disorder and functional proteomics.

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Predrag Radivojac,Lilia M Iakoucheva,Christopher J Oldfield,Zoran Obradovic,Vladimir N Uversky,A Keith Dunker,Predrag Radivojac,Lilia M Iakoucheva,Christopher J Oldfield,Zoran Obradovic,Vladimir N Uversky,A Keith Dunker,

The recent advances in the prediction of intrinsically disordered proteins and the use of protein disorder prediction in the fields of molecular biology and bioinformatics are reviewed here, especially with regard to protein function. First, a close look is taken at intrinsically disordered proteins and then at the methods used for their experimental characterization. Next, the major statistical properties of disordered regions are summarized, and prediction models developed thus far are described, including their numerous applications in functional proteomics. The future of the prediction of protein disorder and the future uses of such predictions in functional proteomics comprise the last section of this article.

Intrinsic disorder and functional proteomics. Publishing Authors By Initials

P Radivojac,LM Iakoucheva,CJ Oldfield,Z Obradovic,VN Uversky,AK Dunker,P Radivojac,LM Iakoucheva,CJ Oldfield,Z Obradovic,VN Uversky,AK Dunker,

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Intrinsic disorder and functional proteomics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 1439-56

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 8

MONTH: 12

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 370626

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AFFILIATION: School of Informatics, Indiana University, Bloomington, Indiana.

Country: United States

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MEDLINETA: Biophys J

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