Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice.

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Research Abstract Details 

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Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Abstract Text:

Lynda M Brown,Deborah J Clegg,Stephen C Benoit,Stephen C Woods,

As the incidence of obesity continues to increase, adequate animal models acquire increased importance for the investigation of energy homeostatic mechanisms. Understanding the central mechanism of action of the adiposity hormones, insulin and leptin, has become particularly important as researchers examine ways to treat or prevent obesity. Although the intra-3rd-ventricular (i3vt) administration of insulin reduces food intake in several species, its effects on food intake and body weight have not been previously been assessed in mice. Male C57BL/6J mice were administered insulin i3vt (0.05, 0.1 or 0.4 microU) or leptin i3vt (5 microg/1 microl) as a positive control. As it occurs in other species, i3vt insulin dose-dependently reduced 24-h food intake and body weight, and increased hypothalamic proopiomelanocortin (POMC) mRNA. Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis.

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Publishing Authors By Initials

LM Brown,DJ Clegg,SC Benoit,SC Woods,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiology & behavior

VOLUME: 89

Page Numbers: 687-91

Journal Abbreviation: Physiol. Behav.

ISSN: 0031-9384

DAY: 18

MONTH: 09

YEAR: 2006

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Information

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LANGUAGE: eng

NlmUniqueID: 151504

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: methods

Chemical & Substance for Abstract: Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Information

Substance Name: Pro-Opiomelanocortin

Registry Number: 66796-54-1

Grant and Affiliation Information for Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice.

AFFILIATION: Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA. lmbrown6@uncg.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK 17844

ACRONYM: DK

MEDLINETA: Physiol Behav

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