Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study.

Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Research Abstract Details 

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Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Abstract Text:

The ideal antihypertensive agent for lowering very high blood pressure levels rapidly in severe hypertension of pregnancy still eludes researchers. This pilot study was conducted to determine the appropriate dosage regimen for isradipine in black patients with severe hypertensive disorders of pregnancy. Ten black patients with gestational age > or = 30 (range 30-38) weeks and diastolic blood pressure (DBP) > or = 110 (range 110-148) mmHg following 2 h of bed rest were recruited following informed consent. None of the patients had symptoms or signs of hypertensive crisis. After correction of hypovolaemia (using central venous pressure monitoring) with Ringer's lactate, high blood pressure was lowered by an isradipine infusion. Fetal heart rate was continuously recorded using a cardiotocograph. All blood pressure measurements were made using the same mercury sphygmomanometer by a single observer. The infusion rate of isradipine was adjusted at regular intervals until blood pressure control (DBP < 95 mmHg) was achieved. The optimal dosage regimen in black patients was found to be an initial dose of 0.15 microgram kg-1 min-1 with increments of 0.0025 micrograms kg-1 min-1 every 15 min until blood pressure control is achieved. Thereafter, a maintenance infusion of 0.15 microgram kg-1 min-1 can be initiated. This dosage regimen is associated with neither maternal hypotension nor fetal heart rate deceleration.

Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Publishing Authors By Initials

For similar female urogenital diseases and pregnancy complications: pregnancy complications: pregnancy complications, cardiovascular research abstracts see: female urogenital diseases and pregnancy complications: pregnancy complications: pregnancy complications, cardiovascular research

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MEDLINE DATE:

Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood pressure. Supplement

VOLUME: 1

Page Numbers: 54-6

Journal Abbreviation:

ISSN: 0803-8023

DAY: 26

MONTH: 02

YEAR: 1994

Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9300787

Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Keywords Mesh Terms:

KEYWORDS: Pregnancy Complications, Cardiovascular

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. Information

Substance Name: Isradipine

Registry Number: 75695-93-1

Grant and Affiliation Information for Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study.

AFFILIATION: Department of Experimental and Clinical Pharmacology, University of Natal Medical School, Durban, South Africa.

Country: NORWAY

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MEDLINETA: Blood Press Suppl

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