Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide.

Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Research Abstract Details 

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Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Abstract Text:

T Yamazaki,M Hayashi,A Komatsuzaki,

In 1974 (6), 6 patients with incapacitating unilateral Meniere's disease were given an empiric treatment with intratympanic gentamicin sulfate via the eustachian tube using a catheter with a small side-branch. These patients showed excellent results, gaining relief from vertigo over a 13-year period. Since 1980 (7. 8), we have treated patients suffering from Menière's disease with isosorbide. When the patients could not be controlled by this therapy, isosorbide was given in addition to intratympanic gentamicin therapy using a tubal catheter. Of 75 patients with Menière's disease who received gentamicin and isosorbide therapy, 41 could be evaluated by the classification of the American Academy of Opthalmology and Otolaryngology (AAOO) in 1987 (9). Three of these patients suffered from repeated attacks of vertigo for 2 years. However, all of them could be easily controlled by additional intratympanic gentamicin or isosorbide therapy on an out-patient basis. Thereafter, of a further 40 patients with incapacitating Menière's disease who received gentamicin and isosorbide therapy, 15 could be evaluated by the AAOO classification. In summary, of the 115 patients with incapacitating Menière's disease treated with intratympanic gentamicin after isosorbide treatment, 56 could be evaluated by the AAOO criteria from 1987 to 1990. These patients ranged in age from 21 to 79 years. Vertigo improved in 80% of the patients: 19 patients (34%) were group A. 22 patients (39%) were group B, 4 patients 7%) were group C and 11 patients (20%) were group D, of whom 9 patients required subsequent endolymphatic-mastoid shunt operations. This treatment also effectively controlled patients with bilateral Menière's disease.

Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Publishing Authors By Initials

T Yamazaki,M Hayashi,A Komatsuzaki,

For similar otorhinolaryngologic diseases: ear diseases: labyrinth diseases: vestibular diseases research abstracts see: otorhinolaryngologic diseases: ear diseases: labyrinth diseases: vestibular diseases research

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Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 481

Page Numbers: 613-6

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1991

Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Keywords Mesh Terms:

KEYWORDS: Vestibular Diseases

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide. Information

Substance Name: Isosorbide Dinitrate

Registry Number: 87-33-2

Grant and Affiliation Information for Intratympanic gentamicin therapy for Menière's disease placed by a tubal catheter with systematic isosorbide.

AFFILIATION: Department of Neurotology, Sapporo City General Hospital, Japan.

Country: SWEDEN

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MEDLINETA: Acta Otolaryngol Suppl

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