Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Abstract Text:

Tong Liu,Xue-Yan Pang,Zhan-Tao Bai,Zhi-Fang Chai,Feng Jiang,Yong-Hua Ji,Tong Liu,Xue-Yan Pang,Zhan-Tao Bai,Zhi-Fang Chai,Feng Jiang,Yong-Hua Ji,Tong Liu,Xue-Yan Pang,Zhan-Tao Bai,Zhi-Fang Chai,Feng Jiang,Yong-Hua Ji,

The present study investigated the involvement of spinal glutamate receptors in the induction and maintenance of the pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch (BmK). (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine hydrogen maleate (MK-801; 40nmol; a non-competitive NMDA receptor antagonist), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 40nmol; a non-NMDA receptor antagonist), dl-amino-3-phosphonopropionic acid (dl-AP3; 100nmol; a group I metabotropic glutamate receptor antagonist) and 4-aminopyrrolidine-2,4-dicarboxylate (APDC; 100nmol; a group II metabotropic glutamate receptor agonist) were employed. On intrathecal injection of glutamate receptor antagonists/agonist before BmK venom administration by 10min, BmK venom-induced spontaneous nociceptive responses could be suppressed by all tested agents. Primary thermal hyperalgesia could be inhibited by MK-801 and dl-AP3, while bilateral mechanical hyperalgesia could be inhibited by CNQX and dl-AP3 and contralateral mechanical hyperalgesia could be inhibited by APDC. On intrathecal injection of glutamate receptor antagonists/agonist after BmK venom injection by 4.5h, primary thermal hyperalgesia could be partially reversed by all tested agents, while bilateral mechanical hyperalgesia could only be inhibited by APDC. The results suggest that the role of spinal glutamate receptors may be different on the various manifestations of BmK venom-induced pain-related behaviors.

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Publishing Authors By Initials

T Liu,XY Pang,ZT Bai,ZF Chai,F Jiang,YH Ji,T Liu,XY Pang,ZT Bai,ZF Chai,F Jiang,YH Ji,T Liu,XY Pang,ZT Bai,ZF Chai,F Jiang,YH Ji,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicon : official journal of the International So

VOLUME: 50

Page Numbers: 1073-84

Journal Abbreviation: Toxicon

ISSN: 0041-0101

DAY: 3

MONTH: 08

YEAR: 2007

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1307333

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.

AFFILIATION: Graduate School of the Chinese Academy of Sciences, Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Toxicon

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch Related Publications

• Alpha-toxin interferes with integrin-mediated adhesion and internalization of Staphylococcus aureus by epithelial cells.
• Linkage and association studies of the susceptibility genes for type 2 diabetes.
• Peripheral signals in the control of feeding behavior.
• Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum.
• [Channelopathy of voltage-gated sodium channel]
• [Co-expression of human bone morphogenetic protein-2 and osteoprotegerin in myoblast C2C12]
• [Coordination bonding driving supramolecular self-assembly of tetraphenylporphyrinatozinc (II) with imidazolyl tailed porphyrinatoiron (III) studied by fluorescence spectra and 1H NMR]
• [Development and equivalence evaluation of monosyllable lists of mandarin speech test materials]
• [Development and equivalence evaluation of spondee lists of mandarin speech test materials]
• [Development of monoclonal antibody against fumonisin B1 and ELISA-kit of quantitative analysis for fumonisin B1]
• [Development of portable LED-based NIR integrity wheat component measuring apparatus]
• [Dual-wavelength method for analysis of overlapped high performance liquid chromatographic peaks with multiwavelength diode array detection]
• [Effects of hypothyroidism on apoptosis and the expression of Bcl-2 and Bax gene in the neonatal rat hippocampus neurons]
• [Effects of smoke inhalation injury on the phagocytic function of rat alveolar macrophage and on neutrophil apoptosis]
• [Expression of androgen receptor and estrogen receptor in carcinoma of larynx]
• [Expression of integrin-linked kinase is closely correlated with laryngeal squamous cell carcinomas]
• [Influences of bcr-abl gene vaccine on inoculated SP2/0/bcr-abl tumor cells in mice]
• [Nanomanipulation of sections of human tongue squamous cell carcinoma by atomic force microscopy]
• [Pattern of plasma sex steroid hormone levels during the breeding season of male and female skink: Eumeces chinensis]
• [Recombinant eukaryotic expression plasmid of bcr-abl gene fragment induces specific immune response in mice]
• [Remaining laryngeal flap reconstruction of the hypopharynx in pyriform sinus carcinoma resection]
• [Simultaneous determination of glucose, fructose and sucrose in aqueous solution by short-wavelength near infrared spectroscopy]
• [Spectroscopic investigation of the properties of axial coordination of tailed metalloporphyrins]
• [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]
• [Study of distribution of sinapine in commonly used crude drugs from cruciferous plants]
• [T staying not the single criterion of treating laryngeal cancer with surgical techniques]
• [The observation of palatopharyngeal histopathologic characteristic on the patients with obstructive sleep apnea-hypopnea syndrome]
• [The visible spectra study of the conformation equilibrium of iron-metal-free porphyrin dimers]
• [Transmission disequilibrium test for congenital dislocation of the hip and HOXB9 gene or COL1AI gene]
• [Two questions about "Understanding the hemorrhage due to late onset vitamin K deficiency"]