Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells.

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Abstract Text:

Kristy L Edgtton,Joshua Y Kausman,Ming Li,Kim O'Sullivan,Cecilia Lo,Paul Hutchinson,Hideo Yagita,Stephen R Holdsworth,A Richard Kitching,

Dendritic cells in the kidney take up antigens, but little is known about their role in providing co-stimulatory signals for the activation of CD4(+) cells. This study examined the phenotype of dendritic cells in the renal interstitium and in the lymph node draining the kidney before and after intrarenal ovalbumin injection. After intrarenal injection of the antigen, expression of the co-stimulatory molecules CD86 and programmed cell death ligand 1 (PD-L1) increased on renal dendritic cells, whereas expression of only CD86 increased on dendritic cells of the draining lymph node. The activation and proliferation of antigen-specific CD4(+) cells in the lymph node were assessed by transfer of naïve, fluorescently labeled ovalbumin-specific T cell receptor transgenic cells to mice before antigen administration. Blocking both CD86 and CD80 profoundly inhibited CD4(+) cell proliferation, but CD86 was the dominant CD28 ligand in the early proliferative response of CD4(+) cells. Conversely, activation of PD-1, the receptor expressed on CD4(+) cells that binds PD-L1 and PD-L2, reduced the proliferation of CD4(+) cells in the draining lymph node. Comparing subcutaneous and intrarenal administration of antigen, it was found that CD4(+) cell activation was slower and the effects of combined CD80 and CD86 blockade were more profound when antigen was presented via the kidney compared with the skin. In summary, renal dendritic cells take up antigen and participate in the control of antigen-specific CD4(+) cell proliferation by upregulating co-stimulatory molecules such as CD86 that stimulate CD4(+) cell proliferation and by signaling through PD-1, which prevents an inappropriately exuberant immune response.

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Publishing Authors By Initials

KL Edgtton,JY Kausman,M Li,K O'Sullivan,C Lo,P Hutchinson,H Yagita,SR Holdsworth,AR Kitching,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Society of Nephrology : JA

VOLUME: 19

Page Numbers: 515-26

Journal Abbreviation: J. Am. Soc. Nephrol.

ISSN: 1533-3450

DAY: 9

MONTH: 01

YEAR: 2008

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9013836

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells.

AFFILIATION: Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia richard.kitching@med.monash.edu.au.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Soc Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells Related Publications

• A new approach to idiopathic nephrotic syndrome.
• Capripoxviruses: an emerging worldwide threat to sheep, goats and cattle.
• Diphtheria immunization in high-school students.
• Evaluation of an ovine testis cell line (OA3.Ts) for propagation of capripoxvirus isolates and development of an immunostaining technique for viral plaque visualization.
• HETEROPHORIA AND NEUROSIS IN FLYING PERSONNEL.
• Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells.
• Osmoregulatory capacity of contractile vacuoles.
• Our public image.
• Preoperative cardiopulmonary exercise testing.
• Psychiatric beds in a general ward; a year's experience.
• Salvage oesophagectomy after local failure of definitive chemoradiotherapy (Br J Surg 2007; 94: 1059-1066).
• TREATMENT OF PERSISTENT ADULT ENURESIS BY AFFECTUAL DISSOCIATION.
• The health officer and poliomyelitis.
• The physiology of contractile vacuoles; temperature and osmotic stress.
• The physiology of contractile vacuoles; the effects of short-term variations of temperature on a fresh-water peritrich ciliate.
• The prognosis and treatment of melancholia.
• The prognosis of mental disorder.
• Total synthesis and absolute stereochemistry of plakortone D.