Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.

Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Research Abstract Details 

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Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Abstract Text:

Takeshi Ichinohe,Akira Kawaguchi,Shin-ichi Tamura,Hidehiro Takahashi,Hirofumi Sawa,Ai Ninomiya,Masaki Imai,Shigeyuki Itamura,Takato Odagiri,Masato Tashiro,Joe Chiba,Tetsutaro Sata,Takeshi Kurata,Hideki Hasegawa,Takeshi Ichinohe,Akira Kawaguchi,Shin-ichi Tamura,Hidehiro Takahashi,Hirofumi Sawa,Ai Ninomiya,Masaki Imai,Shigeyuki Itamura,Takato Odagiri,Masato Tashiro,Joe Chiba,Tetsutaro Sata,Takeshi Kurata,Hideki Hasegawa,

The avian H5N1 influenza virus has the potential to cause a new pandemic. Since it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to produce vaccines that confer cross-protective immunity. Mucosal vaccine administration was reported to induce cross-protective immunity by inducing secretion of IgA at the mucosal surface. Adjuvants can also enhance the development of fully protective mucosal immunity. Here we show that a new mucosal adjuvant, poly I:poly C12U (Ampligen), a Toll-like receptor 3 agonist proven to be safe in a Phase III human trial, is an effective adjuvant for H5N1 influenza vaccination. Intranasal administration of a candidate influenza vaccine with Ampligen resulted in secretion of IgA, and protected mice that were subsequently challenged with homologous A/Vietnam/1194/2004 and heterologous A/HK/483/97 and A/Indonesia/6/2005 virus.

Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Publishing Authors By Initials

T Ichinohe,A Kawaguchi,S Tamura,H Takahashi,H Sawa,A Ninomiya,M Imai,S Itamura,T Odagiri,M Tashiro,J Chiba,T Sata,T Kurata,H Hasegawa,T Ichinohe,A Kawaguchi,S Tamura,H Takahashi,H Sawa,A Ninomiya,M Imai,S Itamura,T Odagiri,M Tashiro,J Chiba,T Sata,T Kurata,H Hasegawa,

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Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbes and infection / Institut Pasteur

VOLUME: 9

Page Numbers: 1333-40

Journal Abbreviation: Microbes Infect.

ISSN: 1286-4579

DAY: 1

MONTH: 07

YEAR: 2007

Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Information

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LANGUAGE: eng

NlmUniqueID: 100883508

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Grant and Affiliation Information for Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.

AFFILIATION: Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan.

Country: France

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MEDLINETA: Microbes Infect

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