Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein.

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Abstract Text:

Colleen Olive,Hsien Kuo Sun,Mei-Fong Ho,Joanne Dyer,Aniko ,Istvan Toth,Michael F Good,

BACKGROUND: We investigated the lipid core peptide (LCP) system for mucosal vaccine delivery against infection with group A streptococcus (GAS)--the causative pathogen of rheumatic fever and rheumatic heart disease. METHODS: An LCP vaccine formulation containing 2 different peptide epitopes of the antiphagocytic M protein of GAS--a conformational epitope from the carboxyterminal conserved C-repeat region and an aminoterminal serotypic epitope--was intranasally administered to mice with cholera toxin B subunit or without additional adjuvant. RESULTS: Our data demonstrate that the LCP vaccine formulation induced the elicitation of antigen-specific systemic immunoglobulin G responses when administered with or without cholera toxin B subunit, whereas cholera toxin B subunit was required for the induction of antigen-specific mucosal immunoglobulin A responses. Immune serum samples from vaccinated mice were capable of opsonization of a homologous GAS strain, as well as opsonization of a heterologous GAS strain. Furthermore, mice were protected from GAS challenge following immunization with the LCP vaccine formulation, even in the absence of additional adjuvant. CONCLUSIONS: These data support the potential of the LCP system in the development of a self-adjuvanting, synthetic, peptide-based mucosal GAS vaccine for the prevention of diseases caused by GAS.

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Publishing Authors By Initials

C Olive,HK Sun,MF Ho,J Dyer,A ,I Toth,MF Good,

For similar complex mixtures: biological products: vaccines: vaccines, subunit research abstracts see: complex mixtures: biological products: vaccines: vaccines, subunit research

PUBMED ID PMID:

MEDLINE DATE:

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 194

Page Numbers: 316-24

Journal Abbreviation: J. Infect. Dis.

ISSN: 1537-6613

DAY: 30

MONTH: 06

YEAR: 2006

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Keywords Mesh Terms:

KEYWORDS: Vaccines, Subunit

MESH TERMS: immunology

Chemical & Substance for Abstract: Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Information

Substance Name: streptococcal M protein

Registry Number: 0

Grant and Affiliation Information for Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein.

AFFILIATION: Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. colleenO@qimr.edu.au

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Infect Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein Related Publications

• A case for whole-parasite malaria vaccines.
• A rapid method to measure beta-amyloid induced neurotoxicity in vitro.
• A small epidemic with meningeal symptoms simulating leptospiral infection.
• Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease.
• Antigen-antibody mechanisms in neurotropic virus diseases.
• Attenuation of beta-amyloid induced toxicity by sialic acid-conjugated dendrimeric polymers.
• Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment.
• Culture and stigma: adding moral experience to stigma theory.
• Determinants of complementary and alternative medicine use by patients with bipolar disorder.
• Diagnosis and treatment of low backache.
• Effects of celecoxib on blood loss, pain, and recovery of function after total knee replacement: a randomized placebo-controlled trial.
• Energy balance pathways converging on the Nhlh2 transcription factor.
• Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability.
• Group clinic starts a new chapter in the history of rural medical care.
• Immunodeficiency, radiosensitivity, and the XCIND syndrome.
• Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein.
• Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group A streptococcus challenge and reduces throat colonization.
• Introduction: Robert A. Good Immunology Conference 2007.
• Lack of identity of hyaluronidase inhibitor and certain mucoproteins in blood serum.
• Nongenomic actions of aldosterone on the renal tubule.
• Novel DOCK clique driven 3D similarity database search tools for molecule shape matching and beyond: adding flexibility to the search for ligand kin.
• Reliability and Validity of the Sensewear Pro Armband During Continuous Functional Resistance Exercise: 1301: Board #64 May 30 9:30 AM - 11:00 AM.
• Response 2.
• Robert A Good and Ludwig van Beethoven: immortal beloveds: summary of the Robert A Good Immunology Society: Perspective in Immunology 2006 June 9-12 2006 St. Pete Beach, Florida.
• Robert A. Good, the March of Dimes, and immunodeficiency: an historical perspective.
• Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway.
• Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning.
• Technology and retinopathy of prematurity diagnosis: the new frontier.
• The importance of exploratory thoracotomy in the diagnosis of certain pulmonary lesions.
• The spectrum of vision impairment caused by pediatric neurological injury.