Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams.

Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. Research Abstract Details 

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Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. Abstract Text:

Santos Fustero, ,Paula Bello,Carlos Del Pozo,Satoru Arimitsu,Gerald B Hammond,

Functionalized gem-difluoro beta- and gamma-lactams were synthesized through a novel intramolecular hydroamination reaction of difluoropropargyl amides. beta-Lactams were obtained via a Baldwin disfavored 4-exo-digonal cyclization using palladium acetate as the catalyst, whereas gamma-lactams were produced under basic conditions. Acid hydration of gamma-lactams produced ketoamides or hemiaminals selectively.

Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. Publishing Authors By Initials

S Fustero,B ,P Bello,CD Pozo,S Arimitsu,GB Hammond,

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Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 9

Page Numbers: 4251-3

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 19

MONTH: 09

YEAR: 2007

Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams.

AFFILIATION: Departamento de Química OrgAnica, Universidad de Valencia, E-46100 Burjassot, Spain. santos.fustero@uv.es

Country: United States

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