Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART.

Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART. Research Abstract Details 

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Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART. Abstract Text:

Thomas Kuntzen,Cristina Tural,Bin Li,Georg Feldmann,Bernd Kupfer,Hans Dieter Nischalke,Bonaventura Clotet,Tilman Sauerbruch,Juergen K Rockstroh,Ulrich Spengler,Thomas Kuntzen,Cristina Tural,Bin Li,Georg Feldmann,Bernd Kupfer,Hans Dieter Nischalke,Bonaventura Clotet,Tilman Sauerbruch,Juergen K Rockstroh,Ulrich Spengler,

OBJECTIVE: Liver disease is more progressive in HIV/hepatitis C virus (HCV) co-infection than in HCV infection alone. This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines. METHODS: Using quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) we studied intrahepatic messenger RNA levels of cytokines and cellular markers defining distinct subsets of inflammatory cells in liver biopsies from 33 HCV-mono-infected and 40 HIV/HCV-co-infected patients. RESULTS: Despite their well preserved peripheral blood CD4 cell counts (median 598 cells/microl), HIV/HCV-co-infected patients displayed significantly lower CD4 mRNA levels than HCV-mono-infected patients, whereas increased mRNA levels of CD3epsilon, TCRalpha, CD8alpha and CD8beta suggested intrahepatic enrichment of CD8 T cells in HIV co-infection. Intrahepatic mRNA levels of the inflammatory cytokines interferon gamma (IFN-gamma), regulated upon activation, normal T-cell expressed and secreted (RANTES, CCL5), macrophage inflammatory protein 1 alpha (CCL3) and interferon-inducible protein 10 (CXCL10) were significantly higher in HIV-positive than in HIV-negative patients, whereas mRNA levels of the profibrogenic cytokines macrophage chemoattractant protein 1 (CCL2), secondary lymphochemokine (CCL21) and stroma-derived factor 1 (CXCL12) did not differ between the two groups. All changes were less pronounced in the subgroup of HIV-positive patients receiving antiretroviral treatment (HAART) than in untreated HIV-positive patients. CONCLUSION: The accelerated liver disease observed in HIV/HCV-co-infected patients might reflect enhanced intrahepatic inflammatory responses rather than increased local transcription of directly profibrogenic cytokines.

Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART. Publishing Authors By Initials

T Kuntzen,C Tural,B Li,G Feldmann,B Kupfer,HD Nischalke,B Clotet,T Sauerbruch,JK Rockstroh,U Spengler,T Kuntzen,C Tural,B Li,G Feldmann,B Kupfer,HD Nischalke,B Clotet,T Sauerbruch,JK Rockstroh,U Spengler,

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Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AIDS (London, England)

VOLUME: 22

Page Numbers: 203-10

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ISSN: 1473-5571

DAY: 11

MONTH: Jan

YEAR: 2008

Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART. Information

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LANGUAGE: eng

NlmUniqueID: 8710219

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AFFILIATION: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. tkuntzen@partners.org

Country: England

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MEDLINETA: AIDS

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