Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders.

Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Research Abstract Details 

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Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Abstract Text:

J Bauman,W L Campbell,A J Demetris,A B Zajko,

We investigated the cholangiographic appearance of intrahepatic bile ducts in 56 liver transplants and correlated the findings with biopsy evidence of acute rejection and other histologic diagnoses. Mild to moderate narrowing, stretching, separation, and poor filling of the bile ducts were common. Narrowing was present in 69 (92%) of 75 studies and was at least moderate in degree in 14 (19%). Duct separation was seen on 39 (58%) of 67 cholangiograms and was usually mild but was more pronounced in 10 (15%). In 22 (25%) of 89 studies, 10 or fewer branch ducts were filled. Cholangiographic abnormalities were more marked in patients with biopsy diagnoses of moderate-severe and partially treated acute rejection than with findings of mild rejection or nonspecific histology. Portal tract cellular infiltration and edema, liver swelling and, possibly, loss of small bile ducts correlated with the radiologic changes. However, the severity of the radiographic changes varied in all histologic categories. Acute rejection contributes to intrahepatic duct narrowing, separation, and poor filling on cholangiography in liver transplants, but the cause of the changes is probably multifactorial. Cholangiography is limited as a test for rejection and other hepatic parenchymal abnormalities in individual patients, but it may provide evidence supporting the need for liver biopsy in the evaluation of hepatic dysfunction after transplantation.

Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Publishing Authors By Initials

J Bauman,WL Campbell,AJ Demetris,AB Zajko,

For similar surgical procedures, operative: digestive system surgical procedures: liver transplantation research abstracts see: surgical procedures, operative: digestive system surgical procedures: liver transplantation research

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Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 152

Page Numbers: 275-9

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ISSN: 0361-803X

DAY: 15

MONTH: Feb

YEAR: 1989

Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders. Keywords Mesh Terms:

KEYWORDS: Liver Transplantation

MESH TERMS: radiography

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Grant and Affiliation Information for Intrahepatic cholangiographic abnormalities in liver transplants: correlation with biopsy evidence of rejection and other disorders.

AFFILIATION: Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, PA 15213.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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