Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages.

Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Research Abstract Details 

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Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Abstract Text:

Jorge Cervantes,Toshi Nagata,Masato Uchijima,Kiyoshi Shibata,Yukio Koide,Jorge Cervantes,Toshi Nagata,Masato Uchijima,Kiyoshi Shibata,Yukio Koide,Jorge Cervantes,Toshi Nagata,Masato Uchijima,Kiyoshi Shibata,Yukio Koide,

Listeria monocytogenes induces apoptosis in vitro and in vivo in a variety of cell types. However, the mechanism of cell death in L. monocytogenes-infected macrophages was initially reported to be distinct from apoptosis. Here, we studied the mechanism of L. monocytogenes-induced cell death using sensitive fluorescent techniques. We found that caspase-1 activation preceded cell death of macrophages infected with L. monocytogenes, using fluorogenic substrates. Caspase-1 activation was diminished after infection with wild-type L. monocytogenes when cells were treated with NH(4)Cl, or if they were infected with a listeriolysin mutant that cannot escape from the phagolysosome. Mitochondrial membrane integrity was preserved during the infection. A particular mechanism of cell death, recently termed 'pyroptosis', is associated with infection by intracellular microorganisms, and has an inherent pro-inflammatory character, due to involvement of caspase-1 activation with consequent IL-1beta and IL-18 production. Cell death through caspase-1 activation would constitute a defence mechanism of macrophages which induces cell death to eliminate the bacteria's intracytosolic niche and recruits early host's defences through the secretion of inflammatory cytokines.

Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Publishing Authors By Initials

J Cervantes,T Nagata,M Uchijima,K Shibata,Y Koide,J Cervantes,T Nagata,M Uchijima,K Shibata,Y Koide,J Cervantes,T Nagata,M Uchijima,K Shibata,Y Koide,

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Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cellular microbiology

VOLUME: 10

Page Numbers: 41-52

Journal Abbreviation: Cell. Microbiol.

ISSN: 1462-5814

DAY: 29

MONTH: 07

YEAR: 2007

Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages.

AFFILIATION: Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan.

Country: England

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MEDLINETA: Cell Microbiol

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