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Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats.

Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats. Research Abstract Details 

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  • Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats. Abstract Text:

    The present study evaluated the effects of intracranial administration of amphetamine (AMPH) on paced mating behavior and open field activity in sexually receptive female rats. In Experiment 1, AMPH (0.5 microl of 10 microg/microl) or vehicle was infused bilaterally into the medial preoptic area (mPOA). In Experiments 2 and 3, AMPH (0.5 microl of 40 microg/microl) or vehicle was infused bilaterally into the shell region of the nucleus accumbens (NAc) or core region of the NAc, respectively. In Experiment 1, infusions of AMPH into the mPOA increased the latency to return to the male following sexual stimulation without affecting locomotor activity in the open field test. However, when AMPH was infused 3.0 mm dorsal to the mPOA, no effects were observed. In Experiments 2 and 3, infusions of AMPH into the NAc shell or core significantly increased locomotor activity during the open field test but failed to affect most measures of paced mating behavior. Together these results suggest that amphetamine-stimulate dopamine release in the mPOA but not in the NAc alters paced mating behavior, confirming previous conclusions that the mPOA plays a critical role in female sexual behavior, whereas the NAc plays a relatively limited role.

    Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats. Publishing Authors By Initials

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    Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Pharmacology, biochemistry, and behavior

    VOLUME: 89

    Page Numbers: 253-62

    Journal Abbreviation: Pharmacol. Biochem. Behav.

    ISSN: 0091-3057

    DAY: 31

    MONTH: 12

    YEAR: 2007

    Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats. Information

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    LANGUAGE: eng

    NlmUniqueID: 367050

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    Grant and Affiliation Information for Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats.

    AFFILIATION: Department of Psychology, Southwestern University, Georgetown, TX 78626, United States.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Pharmacol Biochem Behav

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