Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats.

Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Research Abstract Details 

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Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Abstract Text:

The effect of intracerebroventricular (i.c.v.) treatment with a vasopressin (AVP) V1-receptor antagonist on the pressor response to i.c.v. injection of clonidine was investigated in conscious rats with chronic i.c.v. guide cannulas and an arterial catheter. In conscious rats, i.c.v.-injected clonidine (5 and 10 micrograms) dose-dependently produced a pressor response with a decrease in heart rate. No significant depressor response was induced by clonidine. The i.c.v. pretreatment with an AVP V1-receptor antagonist ([d(CH2)5-Tyr(Me)]-AVP) at 0.5-2.5 micrograms dose-dependently inhibited the pressor response to 10 micrograms of i.c.v.-injected clonidine, while systemic (i.v.) pretreatment with the antagonist (2.5 micrograms) had no effect. In pentobarbital-anesthetized rats, 10 micrograms of i.c.v.-injected clonidine caused a marked depressor response associated with bradycardia. However, i.c.v. pretreatment with the antagonist (2.5 micrograms) did not affect cardiovascular responses to i.c.v.-injected clonidine. These results suggest that endogenous AVP in the brain is involved in the mechanisms underlying the pressor response to i.c.v.-injected clonidine in conscious rats.

Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Publishing Authors By Initials

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Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Japanese journal of pharmacology

VOLUME: 63

Page Numbers: 447-53

Journal Abbreviation: Jpn. J. Pharmacol.

ISSN: 0021-5198

DAY: 16

MONTH: Dec

YEAR: 1993

Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Information

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LANGUAGE: eng

NlmUniqueID: 2983305

Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Keywords Mesh Terms:

KEYWORDS: Receptors, Vasopressin

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats. Information

Substance Name: vasopressin, 1-(1-mercaptocyclohexaneace

Registry Number: 73168-24-8

Grant and Affiliation Information for Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats.

AFFILIATION: Department of Pharmacology, Miyazaki Medical College, Japan.

Country: JAPAN

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MEDLINETA: Jpn J Pharmacol

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