Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism.

Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism. Research Abstract Details 

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Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism. Abstract Text:

Mikhail V Schepetilnikov,Andrey G Solovyev,Elena N Gorshkova,Joachim Schiemann,Alexey I Prokhnevsky,Valerian V Dolja,Sergey Y Morozov,Mikhail V Schepetilnikov,Andrey G Solovyev,Elena N Gorshkova,Joachim Schiemann,Alexey I Prokhnevsky,Valerian V Dolja,Sergey Y Morozov,Mikhail V Schepetilnikov,Andrey G Solovyev,Elena N Gorshkova,Joachim Schiemann,Alexey I Prokhnevsky,Valerian V Dolja,Sergey Y Morozov,

The membrane-spanning protein TGBp3 is one of the three movement proteins (MPs) of Poa semilatent virus. TGBp3 is thought to direct other viral MPs and genomic RNA to peripheral bodies located in close proximity to plasmodesmata. We used the ectopic expression of green fluorescent protein-fused TGBp3 in epidermal cells of Nicotiana benthamiana leaves to study the TGBp3 intracellular trafficking pathway. Treatment with inhibitors was used to reveal that the targeting of TGBp3 to plasmodesmata does not require a functional cytoskeleton or secretory system. In addition, the suppression of endoplasmic reticulum-derived vesicle formation by a dominant negative mutant of small GTPase Sar1 had no detectable effect on TGBp3 trafficking to peripheral bodies. Collectively, these results suggested the involvement of an unconventional pathway in the intracellular transport of TGBp3. The determinants of targeting to plasmodesmata were localized to the C-terminal region of TGBp3, including the conserved hydrophilic and terminal membrane-spanning domains.

Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism. Publishing Authors By Initials

MV Schepetilnikov,AG Solovyev,EN Gorshkova,J Schiemann,AI Prokhnevsky,VV Dolja,SY Morozov,MV Schepetilnikov,AG Solovyev,EN Gorshkova,J Schiemann,AI Prokhnevsky,VV Dolja,SY Morozov,MV Schepetilnikov,AG Solovyev,EN Gorshkova,J Schiemann,AI Prokhnevsky,VV Dolja,SY Morozov,

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Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of virology

VOLUME: 82

Page Numbers: 1284-93

Journal Abbreviation: J. Virol.

ISSN: 1098-5514

DAY: 21

MONTH: 11

YEAR: 2007

Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism. Information

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LANGUAGE: eng

NlmUniqueID: 113724

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Grant and Affiliation Information for Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism.

AFFILIATION: Department of Botany and Plant Pathology, Oregon State University, Cordley Hall 2082, Corvallis, OR 97331. doljav@science.oregonstate.edu.

Country: United States

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MEDLINETA: J Virol

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