Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.

Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Research Abstract Details 

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Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Abstract Text:

Cha Xiang Guan,Yan Ru Cui,Min Zhang,Hong Bo Bai,Ravitej Khunkhun,Xiang Fang,Cha Xiang Guan,Yan Ru Cui,Min Zhang,Hong Bo Bai,Ravitej Khunkhun,Xiang Fang,

Vasoactive intestinal peptide (VIP), a non-adrenergic, non-cholinergic neuromediator, plays an important role in maintaining the bronchial tone of the airway and has anti-inflammatory properties. Recently, we reported that VIP enhances wound repair in human bronchial epithelial cells (HBEC). In the present study, we have identified the intracellular signaling molecules that are involved in VIP-mediated wound healing in HBEC. The effects of VIP on wound repair of HBEC were partially blocked by H-7 (a protein kinase C (PKC) inhibitor), W-7 (a calmodulin inhibitor), H-89 (a protein kinase A (PKA) inhibitor), and PD98059 (a specific extracellular signal-regulated kinase (ERK) inhibitor). VIP-induced chemotactic migration was inhibited in the presence of W-7, H-89, PD98059 or H-7. H-7, W-7, and H-89 were also found to decrease VIP-induced expression of Ki67 as well as the proliferation index in HBEC. Furthermore, H-7, W-7, H-89, and PD98059 inhibited the expression of E-cd protein and mRNA induced by VIP. These results suggest that intracellular signaling molecules such as PKA, PKC, ERK, and calmodulin play important role in VIP-mediated wound healing of HBEC.

Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Publishing Authors By Initials

CX Guan,YR Cui,M Zhang,HB Bai,R Khunkhun,X Fang,CX Guan,YR Cui,M Zhang,HB Bai,R Khunkhun,X Fang,

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Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Peptides

VOLUME: 28

Page Numbers: 1667-73

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 1

MONTH: 08

YEAR: 2007

Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

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Grant and Affiliation Information for Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.

AFFILIATION: Department of Physiology, Central South University Xiangya Medical School, Changsha, Hunan 410078, China. gcxdzd91@163.com

Country: United States

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MEDLINETA: Peptides

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