[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats]

[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Research Abstract Details 

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[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Abstract Text:

M Nagata,K Kawazu,Y Midori,M Kojima,E Shirasawa,K Sasaki,

PURPOSE: To confirm the intraocular dynamics of 1% deuterium (D)-labeled alpha-tocopherol acetate (VEA) solution. METHODS: The concentrations of D3-VEA and D3-alpha-tocopherol (VE) derived from D3-VEA in the aqueous humor and lens were measured after instilling 1% D3-VEA continuously into the cul-de-sac of rat eyes for one and three weeks. D3-VEA and D3-VE concentrations were determined by gas chromatograph/mass spectrometry. RESULTS: D3-VEA and D3-VE concentrations in the aqueous humor after one and three weeks of continuous administration were 93.1 and 498.9, and 9.4 and 21.5 ng/ml, respectively. The concentrations in the lens were 15.0 and 6.1, and 9.8 and 4.8 ng/g, respectively. CONCLUSION: The penetration of VEA into the aqueous humor and lens by eyedrop application was confirmed.

[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Publishing Authors By Initials

M Nagata,K Kawazu,Y Midori,M Kojima,E Shirasawa,K Sasaki,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nippon Ganka Gakkai zasshi

VOLUME: 104

Page Numbers: 508-10

Journal Abbreviation: Nippon Ganka Gakkai Zasshi

ISSN: 0029-0203

DAY: 19

MONTH: Jul

YEAR: 2000

[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Information

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LANGUAGE: jpn

NlmUniqueID: 7505716

[Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: [Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats] Information

Substance Name: Deuterium

Registry Number: 7782-39-0

Grant and Affiliation Information for [Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats]

AFFILIATION: Department of Ophthalmology, Kanazawa Medical University, Japan.

Country: JAPAN

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MEDLINETA: Nippon Ganka Gakkai Zasshi

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• [Intracameral and lenticular penetration of locally applied deuterium-labeled vitamin E in rats]