Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary.

Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Research Abstract Details 

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Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Abstract Text:

A thirty-five year old woman presented with bilateral neck, chest wall and back masses. She was 16 weeks pregnant. Lymph node excision revealed metastatic poorly differentiated adenocarcinoma of unknown primary. Abdominal ultrasound showed a mildly enlarged spleen and a 2-3 cm porta hepatis node. All other investigations were negative. The lymph node and cutaneous metastases progressed rapidly so it was decided to initiate systemic chemotherapy with a view to delivery at 28 weeks gestation by Caesarean section. Shortly after the second 3-weekly cycle of cisplatinum chemotherapy the patient suffered severe lower back and hip pain with MRI scan showing multiple bony metastases in the pelvic girdle. Ultrasound revealed the fetus to have been dead for at least 10 days. The products of conception were delivered following medical induction of labour. Two days later the patient suffered a cardiac arrest from which she could not be resuscitated. Placental histology revealed extensive metastases. With the exception of melanoma this has rarely been reported in solid adult malignancy. As a cause of fetal death, placental metastases are extremely rare.

Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Publishing Authors By Initials

For similar neoplasms: pregnancy complications, neoplastic research abstracts see: neoplasms: pregnancy complications, neoplastic research

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Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical oncology (Royal College of Radiologists (

VOLUME: 14

Page Numbers: 213-6

Journal Abbreviation: Clin Oncol (R Coll Radiol)

ISSN: 0936-6555

DAY: 10

MONTH: Jun

YEAR: 2002

Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Information

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LANGUAGE: eng

NlmUniqueID: 9002902

Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary. Keywords Mesh Terms:

KEYWORDS: Pregnancy Complications, Neoplastic

MESH TERMS: complications

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Grant and Affiliation Information for Intra-uterine death resulting from placental metastases in adenocarcinoma of unknown primary.

AFFILIATION: Department of Clinical Oncology, Western General Hospital, Edinburgh, UK. charles.gourley@cancer.org.uk

Country: England

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MEDLINETA: Clin Oncol (R Coll Radiol)

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