Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation.

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Abstract Text:

Argyro Tountopoulou,Bjoern Ahl,Karin Weissenborn,Hartmut Becker,Friedrich Goetz,

INTRODUCTION: The aim of our study was to evaluate the safety and efficacy of intra-arterial (IA) thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute stroke due to occlusion in the anterior or posterior circulation. METHODS: We retrospectively analyzed the clinical and radiological data of 88 consecutive patients with acute ischemic stroke who underwent emergency cerebral angiography for the purpose of subsequent IA thrombolysis. The neurological deficit on admission and discharge was graded using the National Institutes of Health Stroke Scale (NIHSS) score. Baseline computer tomography (CT) scans were examined for any signs indicative of cerebral ischemia. The angiographic findings were classified according to the Thrombolysis in Myocardial Infarction (TIMI) score for myocardial infarction. Follow-up CT scans were examined for hemorrhagic complication. RESULTS: Of the 88 patients who underwent IA thrombolysis, 63 presented with complete or partial arterial occlusion in the suspected perfusion area. In these 63 patients, the median NIHSS score dropped from 15 points on admission to 10 points at discharge. The recanalization rate was 52.6% for partial and complete reperfusion. In-hospital mortality was 20.6% (9.1% for carotid, 44.4% for basilar territory occlusion). Intracerebral bleeding (ICB) occurred in 38.6% of the patients with occlusion in the anterior circulation, resulting in these patients presenting a worse clinical outcome than those without ICB. Only minor extracranial bleedings occurred in 20.6% of patients. Patients with ICB had a significantly higher frequency of ischemic signs on the baseline CT scan. CONCLUSION: Occlusion of a cerebral artery is present in about 75% of the patients eligible for thrombolytic therapy. Intra-arterial thrombolysis using rt-PA in patients with acute ischemic stroke can achieve re-vascularization, although ICB remains the major risk factor affecting its efficacy.

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Publishing Authors By Initials

A Tountopoulou,B Ahl,K Weissenborn,H Becker,F Goetz,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroradiology

VOLUME: 50

Page Numbers: 75-83

Journal Abbreviation:

ISSN: 0028-3940

DAY: 5

MONTH: 10

YEAR: 2007

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1302751

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation.

AFFILIATION: Department of Neurology and Clinical Neurophysiology, Hannover Medical School, 30623, Hannover, Germany, tountopoulou.argyro@mh-hannover.de.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuroradiology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation Related Publications

• Changes in patient attitudes following the implementation of a medical information system.
• Development of a high-throughput screening assay based on the 3-dimensional pannus model for rheumatoid arthritis.
• Direct solar spectral irradiance and transmittance measurements from 350 to 2500 nm.
• Editorial.
• Electrooptical measurements for monitoring metabolite fluxes in acetone-butanol-ethanol fermentations.
• Gravity as a factor of aggregative stability and coagulation.
• Harmonia axyridis ladybug invasion and allergy.
• Health behaviors and weight status among urban and rural children.
• Insulin antibodies in pregnancy.
• Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation.
• Preliminary observations on the circulation in the giraffe.
• REMARKS ON THE CLASSIFICATION OF DERMATOPHYTES.
• Rapid accumulation of an interleukin 17 homolog transcript in Crassostrea gigas hemocytes following bacterial exposure.
• Scales to assess psychosis in Parkinson's disease: Critique and recommendations.
• Surface waves using laser generation and electromagnetic acoustic transducer detection.
• Sympathetic amputation clamp.
• The action of dihydroergocornine on the circulation with special reference to hypertension.
• The diagnosis and treatment of vascular diseases with special consideration of clinical plethysmography and the surgical physiology of the autonomic nervous system.
• The tenuous relationship between atriopeptin and sodium excretion.
• Transection of anterior mitral basal stay chords alters left ventricular outflow dynamics and wall shear stress.
• Transplantation of the pancreas.
• Traumatic transposition of the ulnar nerve in a patient with posteromedial varus rotatory instability of the elbow: a case report.
• Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wild-type p53 allele in only 50% of tumours.
• [Cytogenetic analysis of thioTEPA-induced translocations in the spermatids of male mice]
• [Falls in elderly patients--assessment of falls with reference to etiology and prevention]
• [HORMONE-PRODUCING OVARIAN TUMORS. REPORT ON A CASE OF BENIGN THECA CELL TUMOR IN A PATIENT IN THE MENOPAUSE AND ON A CASE OF MALIGNANT GRANULOSA CELL TUMOR POST PARTUM.]
• [Illness as effect of cultural construction in the enlightenment. The example of hypochondria]
• [On the therapy of premature separation of the normally located placenta.]
• [Struma, hyper- and hypothyroidism]
• [Utilization rates and turnover times as indicators of OR workflow efficiency.]